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前列腺炎在前列腺癌中的作用：荟萃分析。

The role of prostatitis in prostate cancer: meta-analysis.

机构信息

Public Health Institution, The Ohio State University, Columbus, Ohio, United States of America.

Department of Urology, Weill Cornell Medical College, New York, New York, United States of America.

出版信息

PLoS One. 2013 Dec 31;8(12):e85179. doi: 10.1371/journal.pone.0085179. eCollection 2013.

DOI:10.1371/journal.pone.0085179
PMID:24391995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3877315/
Abstract

OBJECTIVE

Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model.

EVIDENCE ACQUISITION

Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio.

SELECTION CRITERIA

the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases.

EVIDENCE SYNTHESIS

In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95%CI: 1.39-1.62), and random effects model (OR=1.64, 95%CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95%CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95%CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95%CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95%CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95%CI: 1.34-1.57; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95%CI: 1.25-1.80; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90.

CONCLUSIONS

the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.

摘要

目的

采用系统评价方法，在固定效应模型和随机效应模型下定量评估前列腺炎与前列腺癌之间的关联。

证据获取

针对前列腺癌的病例对照研究，其中包含前列腺炎病史信息。收集了 1990 年至 2012 年间发表的所有研究，以计算合并优势比。

选择标准

选择标准如下：人类病例对照研究；1990 年 5 月至 2012 年 7 月发表；包含前列腺炎和前列腺癌病例数。

证据综合

共纳入 20 项病例对照研究。在固定效应模型（合并优势比[OR] = 1.50，95%置信区间[CI]：1.39-1.62）和随机效应模型（OR = 1.64，95%CI：1.36-1.98）下，均发现前列腺炎与前列腺癌之间存在显著关联。基于个人访谈的病例对照研究显示出较高的关联水平（固定效应模型：合并 OR = 1.59，95%CI：1.47-1.73；随机效应模型：合并 OR = 1.87，95%CI：1.52-2.29），与基于临床的研究相比（固定效应模型：合并 OR = 1.05，95%CI：0.86-1.28；随机效应模型：合并 OR = 0.98，95%CI：0.67-1.45）。此外，还计算了每个十年的合并优势比。在固定效应模型中：1990 年代：OR = 1.58，95%CI：1.35-1.84；2000 年代：OR = 1.59，95%CI：1.40-1.79；2010 年代：OR = 1.37，95%CI：1.22-1.56。在随机效应模型中：1990 年代：OR = 1.98，95%CI：1.08-3.62；2000 年代：OR = 1.64，95%CI：1.23-2.19；2010 年代：OR = 1.34，95%CI：1.03-1.73。最后，对每个国家进行了分层荟萃分析。在固定效应模型中，美国：合并 OR = 1.45，95%CI：1.34-1.57；中国：合并 OR = 4.67，95%CI：3.08-7.07；古巴：合并 OR = 1.43，95%CI：1.00-2.04；意大利：合并 OR = 0.61，95%CI：0.13-2.90。在随机效应模型中，美国：合并 OR = 1.50，95%CI：1.25-1.80；中国：合并 OR = 4.67，95%CI：3.08-7.07；古巴：合并 OR = 1.43，95%CI：1.00-2.04；意大利：合并 OR = 0.61，95%CI：0.13-2.90。

结论

本荟萃分析提供了统计学证据，表明前列腺炎与前列腺癌之间存在显著关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/3877315/ba567c76f1e1/pone.0085179.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/3877315/ba567c76f1e1/pone.0085179.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e96b/3877315/c7f957b8b657/pone.0085179.g002.jpg
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