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老年齿状突骨折患者的生存分析。

Survival analysis of elderly patients with a fracture of the odontoid peg.

机构信息

University Hospitals of Leicester, Infirmary Square, Leicester LE1 5WW, UK.

出版信息

Bone Joint J. 2014 Jan;96-B(1):88-93. doi: 10.1302/0301-620X.96B1.32024.

Abstract

Fractures of the odontoid peg are common spinal injuries in the elderly. This study compares the survivorship of a cohort of elderly patients with an isolated fracture of the odontoid peg versus that of patients who have sustained a fracture of the hip or wrist. A six-year retrospective analysis was performed on all patients aged > 65 years who were admitted to our spinal unit with an isolated fracture of the odontoid peg. A Kaplan-Meier table was used to analyse survivorship from the date of fracture, which was compared with the survivorship of similar age-matched cohorts of 702 consecutive patients with a fracture of the hip and 221 consecutive patients with a fracture of the wrist. A total of 32 patients with an isolated odontoid fracture were identified. The rate of mortality was 37.5% (n = 12) at one year. The period of greatest mortality was within the first 12 weeks. Time made a lesser contribution from then to one year, and there was no impact of time on the rate of mortality thereafter. The rate of mortality at one year was 41.2% for male patients (7 of 17) compared with 33.3% for females (5 of 15). The rate of mortality at one year was 32% (225 of 702) for patients with a fracture of the hip and 4% (9 of 221) for those with a fracture of the wrist. There was no statistically significant difference in the rate of mortality following a hip fracture and an odontoid peg fracture (p = 0.95). However, the survivorship of the wrist fracture group was much better than that of the odontoid peg fracture group (p < 0.001). Thus, a fracture of the odontoid peg in the elderly is not a benign injury and is associated with a high rate of mortality, especially in the first three months after the injury.

摘要

齿状突骨折是老年人常见的脊柱损伤。本研究比较了一组老年患者单纯齿状突骨折与髋部或腕部骨折患者的生存率。对所有年龄>65 岁、因单纯齿状突骨折而入住我院脊柱科的患者进行了一项为期 6 年的回顾性分析。使用 Kaplan-Meier 表分析从骨折发生日期起的生存率,并与 702 例连续髋部骨折和 221 例连续腕部骨折年龄匹配队列的生存率进行比较。共确定 32 例单纯齿状突骨折患者。1 年时死亡率为 37.5%(n=12)。死亡率最高的时期是前 12 周。从那时到 1 年时,时间的影响较小,此后时间对死亡率没有影响。男性患者 1 年死亡率为 41.2%(17 例中有 7 例),女性为 33.3%(15 例中有 5 例)。髋部骨折患者 1 年死亡率为 32%(702 例中有 225 例),腕部骨折患者为 4%(221 例中有 9 例)。髋部骨折和齿状突骨折的死亡率无统计学差异(p=0.95)。然而,腕部骨折组的生存率明显优于齿状突骨折组(p<0.001)。因此,老年人的齿状突骨折并非良性损伤,与高死亡率相关,尤其是在受伤后的前 3 个月。

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