1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712;
1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712; ; 2. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, USA 78712;
Theranostics. 2013 Dec 5;4(1):36-46. doi: 10.7150/thno.7143. eCollection 2013.
Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demonstrated as a novel imaging modality capable of visualizing both morphology (via IVUS) and cellular/molecular composition (via IVPA) of atherosclerotic plaques, using both endogenous tissue absorbers and exogenous contrast agents. Plasmonic gold nanoparticles were previously utilized as IVPA contrast agents which co-localize with atherosclerotic plaques, particularly phagocytically active macrophages. The present work demonstrates the use of IVUS/IVPA imaging as a tool for localized temperature monitoring during laser heating. The temperature dependent change in IVPA signal intensity of silica-coated gold nanorod contrast agents absorbing within the near-infrared optical wavelength range is evaluated and shown to have a linear relationship, with a slope greater than that of endogenous tissue. A continuous wave laser was subsequently incorporated into the IVUS/IVPA integrated catheter and utilized to selectively heat the nanoparticles with simultaneous IVPA temperature monitoring. IVUS/IVPA, therefore, provides a platform for detection and temperature monitoring of atherosclerotic plaques through the selective heating of plasmonic gold nanoparticle contrast agents.
最近，联合血管内超声和光声（IVUS/IVPA）成像已被证明是一种新的成像方式，能够通过内源性组织吸收剂和外源性对比剂同时可视化动脉粥样硬化斑块的形态（通过 IVUS）和细胞/分子组成（通过 IVPA）。等离子体金纳米粒子以前曾被用作 IVPA 对比剂，与动脉粥样硬化斑块特别是吞噬性活跃的巨噬细胞共定位。本工作证明了将 IVUS/IVPA 成像用作激光加热过程中局部温度监测的工具。评估了吸收在近红外光波长范围内的二氧化硅包覆金纳米棒对比剂的 IVPA 信号强度随温度的变化，结果表明其具有线性关系，斜率大于内源性组织。随后，连续波激光被纳入 IVUS/IVPA 集成导管中，并用于选择性加热纳米粒子，同时进行 IVPA 温度监测。因此，IVUS/IVPA 通过等离子体金纳米粒子对比剂的选择性加热为检测和监测动脉粥样硬化斑块提供了一个平台。
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