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心血管炎症中的纳米颗粒诊疗学

Nanoparticle theranostics in cardiovascular inflammation.

作者信息

MacRitchie Neil, Di Francesco Valentina, Ferreira Miguel Filipe Moreira Marques, Guzik Tomasz J, Decuzzi Paolo, Maffia Pasquale

机构信息

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.

出版信息

Semin Immunol. 2021 Aug;56:101536. doi: 10.1016/j.smim.2021.101536. Epub 2021 Nov 30.

DOI:10.1016/j.smim.2021.101536
PMID:34862118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8811479/
Abstract

Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation.

摘要

治疗诊断学,从字面上看是由诊断和治疗这两个词组合而成,是一个新兴的临床和临床前研究领域,在这个领域中,造影剂、药物和诊断技术相结合,以同时诊断和治疗疾病。纳米颗粒因其能够靶向特定器官的潜力及其多功能性而被广泛应用于治疗诊断学。在这篇综述中,我们将讨论治疗诊断纳米医学的现状,并提供其在心血管炎症成像和治疗中的应用的关键实例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/8811479/9a7776f58551/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/8811479/9a7776f58551/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd1/8811479/9a7776f58551/gr1.jpg

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本文引用的文献

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Nat Rev Immunol. 2022 Apr;22(4):251-265. doi: 10.1038/s41577-021-00584-1. Epub 2021 Aug 13.
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Immune cell profiling in atherosclerosis: role in research and precision medicine.动脉粥样硬化中的免疫细胞分析:在研究和精准医学中的作用。
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Nanomaterials as Novel Cardiovascular Theranostics.纳米材料作为新型心血管诊疗手段
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Luminol-conjugated cyclodextrin biological nanoparticles for the treatment of severe burn-induced intestinal barrier disruption.用于治疗严重烧伤引起的肠屏障破坏的鲁米诺共轭环糊精生物纳米颗粒。
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Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery.纳米医学与基于纳米颗粒的整形外科和重建外科递送系统。
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