Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents .
Gynecol Endocrinol. 2014 Mar;30(3):187-91. doi: 10.3109/09513590.2013.860122. Epub 2014 Jan 7.
The cystic mature teratomas, including dermoid cysts, are one of the most frequently occurring benign ovarian tumors diagnosed in female patients. The process of neoplastic transformation in mature dermoid cysts is applicable only to 1-2% of cases. In our article, we present a rare case of thyroid carcinoma development in adult teratoma in 21-year-old patient. The young age, certain pathomorphological features and clinical data (small size of neoplastic lesion, correct values of tumour markers, unilateral character, regular levels of thyreoglobulin and absence of any significant deviations in imaging examinations), were the basis for attempting to apply the conservative treatment both in the scope of gynecological surgery and in the supplemental endocrinological therapy. In the patient, the one-sided adnexectomy was performed, considering pathological lesions on the adnexa, as well as the other ovary dermoid cyst was enucleated, without the hysteroctomy procedure. Considering the lack of any morphological lesions and functional changes relating to thyroid gland, the treatment was not radicalised in this scope, either. At present, one year after the primary operation treatment, the patient does not manifest any disease symptoms, whereas the other ovary, in the follow-up ultrasound examinations, shows normal size and echostructure. The thyroid-stimulating hormone (TSH) suppression keeps being applied.
囊性成熟畸胎瘤，包括皮样囊肿，是女性患者中最常诊断出的良性卵巢肿瘤之一。成熟皮样囊肿的肿瘤性转化过程仅适用于 1-2%的病例。在我们的文章中，我们介绍了一例罕见的 21 岁患者成年畸胎瘤中甲状腺癌发展的病例。年轻的年龄、特定的病理形态学特征和临床数据（肿瘤病变小、肿瘤标志物值正确、单侧特征、甲状腺球蛋白水平正常且影像学检查无明显偏差），为尝试在妇科手术和补充内分泌治疗范围内应用保守治疗提供了依据。在该患者中，由于附件的病理病变，单侧附件切除术得以施行，同时对另一侧卵巢皮样囊肿进行了剔除术，而无需进行子宫切除术。由于与甲状腺相关的形态学病变和功能变化缺乏，在这方面也没有进行激进治疗。目前，在初次手术治疗后一年，患者没有出现任何疾病症状，而在后续的超声检查中，另一侧卵巢显示正常大小和回声结构。促甲状腺激素（TSH）抑制仍在应用。
