Pineyro Maria M, Pereda Jimena, Schou Pamela, de Los Santos Karina, de la Peña Soledad, Caserta Benedicta, Pisabarro Raul
Clínica de Endocrinología y Metabolismo, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Servicio de Anatomía Patológica y Citología, Hospital de la Mujer "Dra Paulina Luisi," Centro Hospitalario Pereira Rossell, ASSE, Montevideo, Uruguay.
Clin Med Insights Endocrinol Diabetes. 2017 Jun 6;10:1179551417712521. doi: 10.1177/1179551417712521. eCollection 2017.
Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed. To our knowledge, this is the third reported case of papillary thyroid microcarcinoma arising within a mature ovarian teratoma without struma ovarii. There is no consensus on the surgical approach and postoperative management of this condition. Whether further therapy with total thyroidectomy and radioiodine ablation may be beneficial is unknown. In conclusion, papillary thyroid microcarcinoma can also arise within mature ovarian teratomas. Although a favorable prognosis is anticipated, there is limited information about its history or prognosis.
成熟囊性畸胎瘤是最常见的卵巢生殖细胞肿瘤。恶性转化并不常见，很少发现甲状腺癌。甲状腺微小乳头状癌很少被描述为与卵巢畸胎瘤相关。我们报告一例34岁女性，她因腹痛和卵巢肿块就诊。手术后，患者被诊断为成熟囊性卵巢畸胎瘤内发生的滤泡型甲状腺微小乳头状癌。基于原发灶较小及患者意愿，未进行进一步治疗。据我们所知，这是第三例报告的成熟卵巢畸胎瘤内发生的甲状腺微小乳头状癌病例，且无卵巢甲状腺肿。对于这种情况的手术方式和术后管理尚无共识。全甲状腺切除术和放射性碘消融的进一步治疗是否有益尚不清楚。总之，甲状腺微小乳头状癌也可发生于成熟卵巢畸胎瘤内。尽管预期预后良好，但其病史或预后的信息有限。
