Rutkowska Aleksandra, Rachoń Dominik
Department of Clinical and Experimental Endocrinology, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk , Gdynia , Poland.
Gynecol Endocrinol. 2014 Apr;30(4):260-5. doi: 10.3109/09513590.2013.871517. Epub 2014 Jan 7.
Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss, women with PCOS usually present with menstrual irregularities and fertility problems.Additionally, they are often characterized by impaired glucose tolerance, which usually leads to the development of type 2 diabetes mellitus (T2DM). This review article describes current and novel approach to the pathomechanisms of PCOS and the potential role of an endocrine disrupting chemical ("endocrine disruptor" - ED) - bisphenol A (BPA), which is commonly used as a plasticizer and due to its molecular structure can interact with estrogen receptors (ERs). Recent observations point to the higher levels of BPA in biological fluids of women with PCOS and its role in the pathogenesis of hyperandrogenism and hyperinsulinemia. It seems that mother's exposure to BPA during pregnancy may also lead to the development of PCOS in the female offspring.
多囊卵巢综合征（PCOS）是绝经前女性中最常见且最具异质性的内分泌紊乱疾病。除了高雄激素血症的体征，如痤疮、多毛和脱发外，PCOS女性通常还存在月经不规律和生育问题。此外，她们常伴有糖耐量受损，这通常会导致2型糖尿病（T2DM）的发生。这篇综述文章描述了PCOS发病机制的当前和新方法，以及一种内分泌干扰化学物质（“内分泌干扰物”——ED）——双酚A（BPA）的潜在作用，双酚A常用作增塑剂，因其分子结构可与雌激素受体（ERs）相互作用。最近的观察结果表明，PCOS女性生物体液中双酚A水平较高，且其在高雄激素血症和高胰岛素血症的发病机制中起作用。母亲在孕期接触双酚A似乎也可能导致雌性后代患PCOS。
