Turk Z, Ljubić S, Boras J
Department of Laboratory Medicine, Vuk Vrhovac Clinic, Zagreb, Croatia.
Physiol Res. 2014;63(2):199-205. doi: 10.33549/physiolres.932559. Epub 2014 Jan 8.
Endogenous secretory receptor (esRAGE) for advanced glycation end-product (AGE) acts as decoy for AGEs. The AGE-to-esRAGE ratio was hypothesized to be implicated in diabetic vasculopathy. We investigated an association of esRAGE and methylglyoxal-adducts serum level, as well as AGE-to-esRAGE ratio in subpopulation of diabetic patients with or without concomitant hyperlipidemia and macrovascular disease in history. In diabetes with concomitant hyperlipidemia esRAGE was significantly decreased compared to hyperlipidemia with normal glucose metabolism (0.306+/-0.2 vs. 0.367+/-0.1; p=0.019) or diabetes alone (0.306+/-0.2 vs. 0.404+/-0.1; p=0.004). High AGE/esRAGE ratio, found in diabetic patients with hyperlipidemia, pointed to increased production of AGEs and low expression of esRAGE. In multivariable analysis adjusted for several confounding factors, increased AGE/esRAGE ratio was recognized as a high risk for vascular disease outcomes.
晚期糖基化终末产物（AGE）的内源性分泌受体（esRAGE）可作为AGE的诱饵受体。据推测，AGE与esRAGE的比值与糖尿病血管病变有关。我们研究了esRAGE与甲基乙二醛加合物血清水平的关联，以及有或无合并高脂血症和既往大血管疾病的糖尿病患者亚组中AGE与esRAGE的比值。与糖代谢正常的高脂血症患者（0.306±0.2对0.367±0.1；p = 0.019）或单纯糖尿病患者（0.306±0.2对0.404±0.1；p = 0.004）相比，合并高脂血症的糖尿病患者中esRAGE显著降低。在合并高脂血症的糖尿病患者中发现的高AGE/esRAGE比值表明AGE生成增加且esRAGE表达降低。在对多个混杂因素进行校正的多变量分析中，AGE/esRAGE比值升高被认为是血管疾病结局的高风险因素。
