Abraham Sam, Wong Hui San, Turnidge John, Johnson James R, Trott Darren J
School of Animal and Veterinary Sciences, University of Adelaide, South Australia 5371, Australia.
J Antimicrob Chemother. 2014 May;69(5):1155-7. doi: 10.1093/jac/dkt518. Epub 2014 Jan 6.
Clinical infections attributed to carbapenemase-producing bacteria are a pressing public health concern owing to limited therapeutic options and linked antimicrobial resistance. In recent years, studies have reported the emergence and spread of carbapenemase-producing Enterobacteriaceae and their public health impact. This has been closely followed by the global dissemination of highly resistant and virulent zooanthroponotic extraintestinal pathogenic Escherichia coli (ExPEC) ST131 clones. It has also been hypothesized that companion animals may act as a reservoir for Gram-negative multidrug-resistant pathogens in the community. Two recent reports have documented the emergence of carbapenemase-producing bacteria in companion animals. This phenomenon is of great concern because of the close contact between humans and their pets, and the potential for cross-species transmission. This scenario suggests a role for multifaceted control of Gram-negative multidrug-resistant infections in companion animals. This short article addresses this issue and identifies steps that could facilitate this process.
由于治疗选择有限以及相关的抗菌药物耐药性，由产碳青霉烯酶细菌引起的临床感染成为紧迫的公共卫生问题。近年来，研究报告了产碳青霉烯酶肠杆菌科细菌的出现和传播及其对公共卫生的影响。紧随其后的是高耐药性和高致病性的人畜共患肠道外致病性大肠杆菌（ExPEC）ST131克隆在全球范围内的传播。也有人推测伴侣动物可能是社区中革兰氏阴性多重耐药病原体的储存宿主。最近的两份报告记录了伴侣动物中产碳青霉烯酶细菌的出现。由于人类与其宠物之间的密切接触以及跨物种传播的可能性，这一现象备受关注。这种情况表明在伴侣动物中对革兰氏阴性多重耐药感染进行多方面控制具有重要作用。这篇短文探讨了这个问题，并确定了有助于这一过程的步骤。
