鼻腔 NK/T 细胞淋巴瘤的眼眶和中枢神经系统侵犯。
Orbital and central nervous system extension of nasal natural killer/T-cell lymphoma.
机构信息
*School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil; †King Khaled Eye Specialist Hospital, Johns Hopkins University; ‡Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, §Department of Pathology, and ‖Department of Radiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
出版信息
Ophthalmic Plast Reconstr Surg. 2014 Jan-Feb;30(1):20-3. doi: 10.1097/IOP.0b013e3182a7500e.
BACKGROUND
To describe a case series of nasal natural killer (NK)/T-cell lymphoma (NKTL) with orbital and central nervous system extension.
METHODS
This is a retrospective study. The medical records of 9 patients with a diagnosis of NKTL were reviewed. All patients had a positive biopsy for CD3, CD56, T-cell-restricted intracellular antigen-1, and granzyme expression and CT imaging of nose, sinuses, orbits, and brain. Five patients were also examined with MRI.
RESULTS
Orbital extension occurred in 6 patients. All had extraocular muscle enlargement and 5 showed signs of perineural spread.
CONCLUSIONS
NKTL is a polymorphous disease. Extraocular muscle involvement and perineural spread are overlooked features that explain dissemination of the tumor to both the orbit and the central nervous system.
背景
描述一组伴有眼眶和中枢神经系统侵犯的鼻腔自然杀伤（NK）/T 细胞淋巴瘤（NKTL）的病例系列。
方法
这是一项回顾性研究。对诊断为 NKTL 的 9 例患者的病历进行了回顾。所有患者的活检均为 CD3、CD56、T 细胞限制性细胞内抗原-1 和颗粒酶表达阳性，且鼻、鼻窦、眼眶和大脑的 CT 成像均为阳性。5 例患者还接受了 MRI 检查。
结果
6 例患者出现眼眶扩展。所有患者均有眼外肌增大，5 例患者有神经周围扩散的迹象。
结论
NKTL 是一种多形性疾病。眼外肌受累和神经周围扩散是被忽视的特征，这些特征解释了肿瘤向眼眶和中枢神经系统的扩散。
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