Osguthorpe J D, Shirley R
Laryngoscope. 1987 Jul;97(7 Pt 1):829-31.
Rhinitis medicamentosa from topical vasoconstrictor abuse results in nasal obstruction which can be life-threatening in neonates. Neonates are obligate nasal breathers, most learning oral respiration by 2 months of age. A neonate was started on topical phenylephrine at birth, and by 3 weeks of age was having multiple daily episodes of apnea and cyanosis. An evaluation documented edematous, obstructing nasal turbinates, as well as polycythemia, cardiomegaly, and prominence of the pulmonary vasculature. A nasopharyngeal airway alleviated the obstruction until the turbinates recovered, and the other abnormalities quickly resolved.
因滥用局部血管收缩剂导致的药物性鼻炎会引起鼻阻塞，这对新生儿可能是危及生命的。新生儿是必须经鼻呼吸的，大多数在2个月大时学会经口呼吸。一名新生儿出生时开始使用局部用去氧肾上腺素，到3周大时每天多次出现呼吸暂停和发绀。一项评估记录显示有水肿、阻塞性鼻甲，以及红细胞增多症、心脏肥大和肺血管突出。一个鼻咽通气管缓解了阻塞，直到鼻甲恢复，其他异常情况也迅速得到解决。
