Todoerti M, Maglione W, Bernero E, Bortoluzzi A, Colaci M, Galuppi E, Paolino S, Talarico R, Cutolo M, Ferri C, Trotta F, Bombardieri S, Montecucco C Maurizio, Sinigaglia L
Rheumatology, IRCCS S. Matteo, University of Pavia.
Reumatismo. 2013 Dec 18;65(5):207-18. doi: 10.4081/reumatismo.2013.207.
The objective of this review is to update the recommendations of the 2010 Italian Consensus on the use of methotrexate (MTX) in rheumatoid arthritis (RA) and other rheumatic diseases. The literature published between 2008 and 2012 was systematically reviewed and updated recommendations on MTX use in rheumatic diseases, particularly RA, were formulated. These recommendations were approved by a panel of expert Italian Rheumatologists. A total of 10,238 references were identified, among which 70 studies were selected for critical evaluation. Sufficient evidence had accumulated to warrant changes to several of the recommendations in the new version. A new recommendation for patients with RA who are in MTX-induced clinical remission was also proposed and approved by the panel. Updated recommendations for the use of MTX in patients with RA or other rheumatologic disease are proposed.
本综述的目的是更新2010年意大利关于甲氨蝶呤（MTX）在类风湿关节炎（RA）及其他风湿性疾病中应用的共识推荐。对2008年至2012年间发表的文献进行了系统回顾，并制定了关于MTX在风湿性疾病，尤其是RA中应用的更新推荐。这些推荐由一组意大利风湿病专家组成的小组批准。共识别出10238篇参考文献，其中70项研究被选作批判性评估。已有足够的证据支持对新版本中的若干推荐进行修改。小组还提出并批准了一项针对处于MTX诱导的临床缓解期的RA患者的新推荐。本文提出了关于MTX在RA或其他风湿性疾病患者中应用的更新推荐。
