Department of Endocrinology, Aalborg University Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark.
Eur J Endocrinol. 2014 Mar 8;170(4):507-17. doi: 10.1530/EJE-13-0918. Print 2014 Apr.
To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID).
A longitudinal population-based study (DanThyr).
We examined 2465 adults before (1997) and after (2008) the Danish IF of salt (2000). Ultrasonography was carried out by the same sonographers using the same equipment, after controlling performances. Participants treated for thyroid disease were excluded from analyses.
Overall, median thyroid volume had increased in Copenhagen (11.8-12.2 ml, P=0.001) and decreased in Aalborg, although not significantly (13.3-13.1 ml, P=0.07) during the 11 years of follow-up. In both regions, there was an age-related trend in individual changes in thyroid volume from baseline to follow-up; thyroid volume increased in women <40 years of age and decreased in women >40 years of age. IN A MULTIVARIATE REGRESSION MODEL, HIGHER AGE AT ENTRY WAS A PREDICTOR (P0.05) FOR THYROID VOLUME DECREASE 20% DURING THE FOLLOW-UP PERIOD (WOMEN AGED 4045 YEARS: odds ratio (OR) 4.3 (95% CI, 2.2-8.2); women aged 60-65 years: 5.8 (2.9-11.6)) and individuals of higher age were also less likely to have an increase in thyroid volume (women aged 40-45 years: OR 0.2 (0.1-0.3); women aged 60-65: OR 0.3 (0.2-0.4)).
Age-dependent differences in thyroid volume and enlargement had leveled out after the Danish iodization program. Thus, the previously observed increase in thyroid volume with age may have been caused by ID.
评估在两个基线碘摄入量不同的丹麦地区（哥本哈根，轻度碘缺乏症（ID）和奥尔堡，中度 ID）实施强制性全国碘强化（IF）计划后个体甲状腺体积的变化。
一项基于人群的纵向研究（DanThyr）。
我们在丹麦 IF 盐（2000 年）之前（1997 年）和之后（2008 年）检查了 2465 名成年人。在控制了性能之后，由同一位超声科医生使用相同的设备进行超声检查。排除了患有甲状腺疾病的患者进行分析。
总体而言，在 11 年的随访期间，哥本哈根的甲状腺体积（11.8-12.2ml，P=0.001）增加，而奥尔堡的甲状腺体积（13.3-13.1ml，P=0.07）虽有所下降。在两个地区，从基线到随访期间，个体甲状腺体积的变化都存在与年龄相关的趋势；年龄<40 岁的女性甲状腺体积增加，年龄>40 岁的女性甲状腺体积减少。在多变量回归模型中，较高的进入年龄是甲状腺体积在随访期间减少 20%的预测因素（P0.05）（年龄 40-45 岁的女性：比值比（OR）4.3（95%CI，2.2-8.2）；年龄 60-65 岁的女性：5.8（2.9-11.6）），年龄较高的个体也不太可能甲状腺体积增加（年龄 40-45 岁的女性：OR 0.2（0.1-0.3）；年龄 60-65 岁的女性：OR 0.3（0.2-0.4））。
丹麦碘化计划实施后，甲状腺体积和肿大的年龄依赖性差异趋于平衡。因此，以前观察到的随着年龄增长甲状腺体积增加可能是由 ID 引起的。
