Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom2Cochrane Tobacco Addiction Group, University of Oxford, Oxford, United Kingdom.
Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
JAMA. 2014 Jan 8;311(2):193-4. doi: 10.1001/jama.2013.283787.
Among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each?
Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events.
在 3 种一线戒烟治疗方法（尼古丁替代疗法[NRT]、安非他酮和伐尼克兰）中，哪种方法最能帮助吸烟者实现并维持至少 6 个月的戒烟，并且每种方法与哪些严重不良事件相关？
与安慰剂（10.6%）相比，NRT（17.6%）和安非他酮（19.1%）的戒烟率更高。伐尼克兰（27.6%）和联合 NRT（31.5%）（例如，贴片加吸入器）最有效地实现戒烟。这些疗法均未与严重不良事件发生率增加相关。
