乙二醇醚混合物的潜在神经毒性效应。
Potential neurotoxic effect of ethylene glycol ethers mixtures.
机构信息
Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland.
出版信息
Pharmacol Rep. 2013;65(5):1415-21. doi: 10.1016/s1734-1140(13)71501-9.
BACKGROUND
Ethylene glycol ethers (EGEs) are widely used as mixtures in various industrial processes and in many household products. 2-Methoxyethanol and 2-ethoxyethanol primarily exert gonadotoxic effect, while 2-butoxyethanol and 2-isopropoxyethanol have potent hemolytic activity. EGEs can cross the blood-brain barrier, but their potential neurodegenerative action in vivo has not been investigated, yet. In the present work, we examined potential adverse effects of EGEs on some selected brain structures.
METHODS
A mixture of two compounds: one with stronger hydrophilic properties (2-methoxyethanol or 2-ethoxyethanol) and the second more lipophilic (2-butoxyethanol or 2-isopropoxyethanol) were administered sc for 4 weeks. Total antioxidant capacity, lipid peroxidation and caspase-3 activity were determined in the frontal cortex and hippocampus.
RESULTS
It has been found that 4-week administration of a mixture of two EGEs, with various intensity, decreased total antioxidant capacity, enhanced lipid peroxidation and increased caspase-3 activity in the frontal cortex and hippocampus of Wistar rat.
CONCLUSION
The obtained results suggested that EGEs exerted adverse effects on the CNS cells and may contribute in pathogenesis of neurodegenerative disorders.
背景
乙二醇醚（EGEs）广泛用作各种工业过程和许多家用产品中的混合物。2-甲氧基乙醇和 2-乙氧基乙醇主要发挥性腺毒性作用，而 2-丁氧基乙醇和 2-异丙氧基乙醇具有很强的溶血活性。EGEs 可以穿过血脑屏障，但它们在体内潜在的神经退行性作用尚未得到研究。在本工作中，我们研究了 EGEs 对一些选定的脑结构的潜在不良影响。
方法
将两种化合物的混合物：一种具有更强的亲水性（2-甲氧基乙醇或 2-乙氧基乙醇），第二种具有更强的亲脂性（2-丁氧基乙醇或 2-异丙氧基乙醇），通过 sc 给药 4 周。在额皮质和海马体中测定总抗氧化能力、脂质过氧化和 caspase-3 活性。
结果
发现两种 EGEs 的混合物，具有不同的强度，在 4 周的给药后，降低了额皮质和海马体中的总抗氧化能力，增强了脂质过氧化作用，并增加了 caspase-3 活性。
结论
研究结果表明，EGEs 对中枢神经系统细胞产生了不良影响，可能有助于神经退行性疾病的发病机制。
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