波多黎各一家性传播感染门诊就诊的高危男性人群肛门 HPV 感染的流行病学研究。
Epidemiology of anal HPV infection in high-risk men attending a sexually transmitted infection clinic in Puerto Rico.
机构信息
Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico ; Department of Health Services Administration, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico ; Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
出版信息
PLoS One. 2014 Jan 6;9(1):e83209. doi: 10.1371/journal.pone.0083209. eCollection 2014.
PURPOSE
Recent studies in Puerto Rico have reported an increasing incidence of anal cancer in Puerto Rican men. The objective of this study was to determine the prevalence, genotype distribution and risk factors associated with anal HPV infection among men attending an STI clinic in Puerto Rico.
METHODS
We conducted a cross-sectional study among 205 men 18 years and older. A comprehensive survey was administered that included a demographic and a behavioral assessment. Separate logistic regression models were performed to determine factors associated with any, high-risk (HR), and multiple anal HPV infection.
RESULTS
The mean age of the study sample was 38.0±13.5 years. The most common HR types were 58, 51 and 31. Overall, HR anal HPV infection was found in 53.5% of the participants. Multiple HPV types in the anal canal were found in 47.6% of the sample. A third (29.8%) of participants reported being men who had sex with men (MSM). MSM had a significantly higher prevalence of any, HR and multiple HPV infection (p-value<0.05). Separate multivariate logistic regression analyses showed that being MSM was associated with any (OR = 4.5; [95%CI: 1.9-10.7]), HR (OR = 3.4; [95%CI: 1.1-10.3) and multiple anal HPV infection (OR = 3.6; [95%CI: 1.5-9.1). HIV was marginally associated with multiple anal HPV infection in multivariate analysis (OR = 3.3; 95%CI = 1.0-11.0).
CONCLUSIONS
Anal HPV is common among sexually active men attending this STI clinic, with higher likelihood of anal HPV infection among MSM.
目的
波多黎各的近期研究报告称，波多黎各男性的肛门癌发病率不断上升。本研究的目的是确定在波多黎各一家性传播感染 (STI) 诊所就诊的男性中，与肛门 HPV 感染相关的流行率、基因型分布和危险因素。
方法
我们对 205 名年龄在 18 岁及以上的男性进行了横断面研究。进行了一项综合调查，包括人口统计学和行为评估。分别进行了逻辑回归模型，以确定与任何、高危 (HR) 和多种肛门 HPV 感染相关的因素。
结果
研究样本的平均年龄为 38.0±13.5 岁。最常见的 HR 型别为 58、51 和 31。总体而言，HR 型肛门 HPV 感染在 53.5%的参与者中发现。在样本中发现 47.6%的人存在多种 HPV 类型。三分之一（29.8%）的参与者报告为男男性行为者（MSM）。MSM 的任何、HR 和多种 HPV 感染的患病率明显更高（p 值<0.05）。单独的多变量逻辑回归分析表明，MSM 与任何（OR=4.5；[95%CI：1.9-10.7]）、HR（OR=3.4；[95%CI：1.1-10.3）和多种肛门 HPV 感染（OR=3.6；[95%CI：1.5-9.1）相关。在多变量分析中，HIV 与多种肛门 HPV 感染呈边缘相关（OR=3.3；95%CI=1.0-11.0）。
结论
在这家性传播感染诊所就诊的活跃男性中，肛门 HPV 很常见，MSM 肛门 HPV 感染的可能性更高。
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