MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
PLoS One. 2012;7(4):e35983. doi: 10.1371/journal.pone.0035983. Epub 2012 Apr 25.
In the recent years, dramatic increases in HIV transmission among men who have sex with men (MSM) have been observed in China. Human papillomavirus (HPV) infection related anal cancer is more common among HIV-infected MSM as compared to the general population. However, HPV infection and anal cytology has been rarely studied in HIV-infected MSM in China.
HIV-infected MSM in Beijing, China were invited to participate in this study between January and April 2011. Anal swabs were collected for examining cytology and HPV genotypes.
Ninety-five eligible participants with complete questionnaire and laboratory data were included in the analyses. Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%). HPV6 (20.0%), HPV16 (10.9%), HPV56 (10.9%), HPV52 (9.1%) and HPV39 (9.1%) were observed most frequently among those with normal anal cytology, while different distribution was found in the ones with abnormal anal cytology as HPV6 (19.4%), HPV16 (19.4%), HPV45 (16.7%), HPV52 (16.7%) and HPV18 (11.1%). In addition, HPV16, HPV45, HPV52 and HPV18 were the most frequent high-risk types in patients with abnormal anal cytology. HPV multiplicity was found to be significantly related to the prevalence of abnormal anal cytology (p for trend = 0.04).
High prevalence of HPV infection and abnormal anal cytology was observed among HIV-infected MSM in China. Infection of multiple HPV types or high-risk types was found to be associated with an increased risk of abnormal anal cytology.
近年来，中国男男性行为者（MSM）中 HIV 传播急剧增加。与一般人群相比，感染 HIV 的 MSM 中与 HPV 感染相关的肛门癌更为常见。然而，在中国，HIV 感染的 MSM 中 HPV 感染和肛门细胞学检查研究甚少。
2011 年 1 月至 4 月，邀请北京的 HIV 感染 MSM 参加这项研究。采集肛门拭子用于检查细胞学和 HPV 基因型。
95 名符合条件的参与者完成了问卷调查和实验室数据，纳入分析。其中 36 名（37.9%）出现异常肛门细胞学表现：非典型鳞状细胞意义不明确（ASC-US）19 例（20.0%），非典型鳞状细胞不能排除高度鳞状上皮内病变（ASC-H）1 例（1.1%），低度鳞状上皮内病变（LSIL）15 例（15.8%），高度鳞状上皮内病变（HSIL）1 例（1.1%）。HPV6（20.0%）、HPV16（10.9%）、HPV56（10.9%）、HPV52（9.1%）和 HPV39（9.1%）在正常肛门细胞学检查中最常见，而异常肛门细胞学检查中分布不同，如 HPV6（19.4%）、HPV16（19.4%）、HPV45（16.7%）、HPV52（16.7%）和 HPV18（11.1%）。此外，HPV16、HPV45、HPV52 和 HPV18 是异常肛门细胞学检查患者中最常见的高危型 HPV。HPV 多重感染与异常肛门细胞学检查的流行率显著相关（趋势检验 p=0.04）。
在中国 HIV 感染的 MSM 中，HPV 感染和异常肛门细胞学检查的流行率很高。感染多种 HPV 型或高危型与异常肛门细胞学检查的风险增加相关。
