Indirubin 3'-monoxime, from a Chinese traditional herbal formula, suppresses viremia in humanized mice infected with multidrug-resistant HIV.
作者信息
Heredia Alonso, Natesan Senthilkumar, Le Nhut M, Medina-Moreno Sandra, Zapata Juan C, Reitz Marvin, Bryant Joseph, Redfield Robert R
机构信息
Institute of Human Virology, University of Maryland School of Medicine , Baltimore, Maryland.
出版信息
AIDS Res Hum Retroviruses. 2014 May;30(5):403-6. doi: 10.1089/aid.2013.0249. Epub 2014 Feb 7.
Abstract
摘要
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Indirubin 3'-monoxime, from a Chinese traditional herbal formula, suppresses viremia in humanized mice infected with multidrug-resistant HIV.来源于一种中国传统草药配方的靛玉红-3'-单肟，可抑制感染耐多药HIV的人源化小鼠的病毒血症。
AIDS Res Hum Retroviruses. 2014 May;30(5):403-6. doi: 10.1089/aid.2013.0249. Epub 2014 Feb 7.
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Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice.用靛玉红3'-单肟靶向CDK9可安全且持久地降低慢性感染人源化小鼠的HIV病毒血症。
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Crystal structure of HIV-1 Tat complexed with human P-TEFb.HIV-1 Tat 与人 P-TEFb 复合物的晶体结构
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Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.靛玉红-3'-单肟可挽救阿尔茨海默病小鼠模型的空间记忆缺陷，并减轻β-淀粉样蛋白相关的神经病理学改变。
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Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication.鉴定能选择性抑制正转录延伸因子（P-TEFb）并阻断HIV-1复制的黄酮哌啶醇类似物。
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Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.一种核苷逆转录酶抑制剂4'-乙炔基-2-氟-2'-脱氧腺苷在使用人外周血单核细胞移植的NOD/SCID Janus激酶3基因敲除小鼠模型中对1型人类免疫缺陷病毒感染具有强效活性。
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Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.直接抑制CDK9可阻断HIV-1复制，同时不会阻止原代人外周血淋巴细胞中的T细胞活化。
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