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Indirubin 3'-monoxime, from a Chinese traditional herbal formula, suppresses viremia in humanized mice infected with multidrug-resistant HIV.

作者信息

Heredia Alonso, Natesan Senthilkumar, Le Nhut M, Medina-Moreno Sandra, Zapata Juan C, Reitz Marvin, Bryant Joseph, Redfield Robert R

机构信息

Institute of Human Virology, University of Maryland School of Medicine , Baltimore, Maryland.

出版信息

AIDS Res Hum Retroviruses. 2014 May;30(5):403-6. doi: 10.1089/aid.2013.0249. Epub 2014 Feb 7.

DOI:10.1089/aid.2013.0249
PMID:24401082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4010160/
Abstract
摘要

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本文引用的文献

1
Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.拟态 CDK9 抑制剂对 HIV-1 激活转录的影响。
J Mol Biol. 2013 Feb 22;425(4):812-29. doi: 10.1016/j.jmb.2012.12.005. Epub 2012 Dec 13.
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New generation humanized mice for virus research: comparative aspects and future prospects.新一代用于病毒研究的人源化小鼠：比较方面和未来前景。
Virology. 2013 Jan 5;435(1):14-28. doi: 10.1016/j.virol.2012.10.007.
3
Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.纳米剂型抗逆转录病毒药物组合在感染 HIV-1 的人外周血淋巴细胞重建小鼠体内的药效学和抗逆转录病毒活性。
J Infect Dis. 2012 Nov 15;206(10):1577-88. doi: 10.1093/infdis/jis395. Epub 2012 Jul 17.
4
CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.CDKI-71，一种新型的 CDK9 抑制剂，与 flavopiridol 相比，对癌细胞具有更强的细胞毒性。
Int J Cancer. 2012 Mar 1;130(5):1216-26. doi: 10.1002/ijc.26127. Epub 2011 Jun 21.
5
Activation of P-TEFb at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime.在双重HIV/TB感染部位激活P-TEFb，并通过CDK9抑制剂靛玉红-3'-单肟抑制结核分枝杆菌诱导的HIV转录激活。
AIDS Res Hum Retroviruses. 2012 Feb;28(2):182-7. doi: 10.1089/aid.2010.0211. Epub 2011 May 6.
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Crystal structure of HIV-1 Tat complexed with human P-TEFb.HIV-1 Tat 与人 P-TEFb 复合物的晶体结构
Nature. 2010 Jun 10;465(7299):747-51. doi: 10.1038/nature09131.
7
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.靛玉红-3'-单肟可挽救阿尔茨海默病小鼠模型的空间记忆缺陷，并减轻β-淀粉样蛋白相关的神经病理学改变。
Neurobiol Dis. 2010 Aug;39(2):156-68. doi: 10.1016/j.nbd.2010.03.022. Epub 2010 Apr 8.
8
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication.鉴定能选择性抑制正转录延伸因子（P-TEFb）并阻断HIV-1复制的黄酮哌啶醇类似物。
Chembiochem. 2009 Aug 17;10(12):2072-80. doi: 10.1002/cbic.200900303.
9
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.一种核苷逆转录酶抑制剂4'-乙炔基-2-氟-2'-脱氧腺苷在使用人外周血单核细胞移植的NOD/SCID Janus激酶3基因敲除小鼠模型中对1型人类免疫缺陷病毒感染具有强效活性。
Antimicrob Agents Chemother. 2009 Sep;53(9):3887-93. doi: 10.1128/AAC.00270-09. Epub 2009 Jun 22.
10
Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.直接抑制CDK9可阻断HIV-1复制，同时不会阻止原代人外周血淋巴细胞中的T细胞活化。
Gene. 2007 Dec 15;405(1-2):65-78. doi: 10.1016/j.gene.2007.09.010. Epub 2007 Sep 19.