丙氯拉嗪对正常前庭眼动和感知反应的影响：一项随机、双盲、交叉、安慰剂对照研究。
Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study.
作者信息
Patel M, Nigmatullina Y, Seemungal B M, Golding J F, Bronstein A M
机构信息
Division of Brain Sciences, Imperial College London, Charing Cross Hospital, London, UK.
出版信息
Audiol Neurootol. 2014;19(2):91-6. doi: 10.1159/000357028. Epub 2013 Dec 21.
BACKGROUND
The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function.
METHODS
We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s(2)) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured.
RESULTS
Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.
背景
本研究调查了丙氯拉嗪是否会影响前庭眼反射（VOR）和前庭感知功能。
方法
在一项针对健康年轻受试者的随机、安慰剂对照、双盲、交叉研究中，我们对12名健康受试者在单次口服5 mg丙氯拉嗪3小时后进行了研究。使用了两种偏航旋转测试：（1）一项阈值任务，用于研究感知运动检测和眼球震颤阈值（加速度步长为0.5°/s²）；（2）对90°/s速度步长的超阈值反应，测量前庭眼和前庭感知的衰减时间常数以及VOR增益。
结果
与安慰剂相比，丙氯拉嗪对任何眼球震颤或感知前庭功能指标均无影响。这种对前庭介导的运动感知缺乏影响表明，该药物可能更多地作为止吐药而非抗眩晕药起作用。
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