Wan Hassan Wan Ahmad Amiruddin, Mohd Nasir Khairul Ridhwan Mohd Nasir, Jamaluddin Saiful Adli, Mohammad Aidid Edre, Hussein Al-Hadeethi Yahia F
Department of Otorhinolaryngology-Head and Neck Surgery, Sultan Ahmad Shah Medical Centre @IIUM (International Islamic University Malaysia), Kuantan, MYS.
Department of Audiology and Speech-Language Pathology, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan, MYS.
Cureus. 2022 Jun 30;14(6):e26452. doi: 10.7759/cureus.26452. eCollection 2022 Jun.
Introduction Vertigo, or the perception of a spinning sensation, is a common symptom experienced by patients who are referred to Otorhinolaryngology clinics. Betahistine is a medication that has been widely used to treat vertigo and its accompanying symptoms. However, the effects of this medication on the vestibulo-ocular reflex (VOR) are still unknown. Initially, it was assumed that betahistine should be discontinued prior to any vestibular tests, particularly the video head impulse test (vHIT). Method Thirty young healthy adults were randomly divided into two equal groups for this randomized double-blind clinical study (betahistine 24 mg and placebo). Baseline pure-tone audiometry (PTA), tympanometry, and VOR measurements were taken, followed by experimental measurements at one hour, four hours, eight hours, and 24 hours after consumption. The video head impulse test (vHIT) was used to determine the VOR. Result Betahistine had no statistically significant effect on vestibulo-ocular reflex gain (F(4,140) = 0.601, p = 0.662). The gain variability across repetitive head impulses remained constant over time. Conclusions Betahistine has no effect on the vestibulo-ocular reflex. As a result, this medication can be taken prior to the vHIT procedure.
引言
眩晕，即对旋转感的感知，是转诊至耳鼻喉科诊所的患者常见的症状。倍他司汀是一种广泛用于治疗眩晕及其伴随症状的药物。然而，这种药物对前庭眼反射（VOR）的影响仍不清楚。最初，人们认为在进行任何前庭测试之前，尤其是视频头脉冲测试（vHIT）之前，应停用倍他司汀。
方法
在这项随机双盲临床研究中，30名年轻健康成年人被随机分为两组，每组人数相等（倍他司汀24毫克组和安慰剂组）。进行了基线纯音听力测定（PTA）、鼓室图和VOR测量，然后在服用后1小时、4小时、8小时和24小时进行实验测量。使用视频头脉冲测试（vHIT）来确定VOR。
结果
倍他司汀对前庭眼反射增益没有统计学上的显著影响（F(4,140) = 0.601，p = 0.662）。随着时间的推移，重复头部脉冲时的增益变异性保持恒定。
结论
倍他司汀对前庭眼反射没有影响。因此，在进行vHIT程序之前可以服用这种药物。
