抗人A红细胞的鼠单克隆抗体：与N-乙酰-D-半乳糖胺的差异反应性
Murine monoclonal antibodies to human A erythrocytes: differential reactivity with N-acetyl-D-galactosamine.
作者信息
Nĕmec M, Drímalová D, Horejsí V, Vanák J, Bártek J, Viklický V
出版信息
Vox Sang. 1987;52(1-2):125-8. doi: 10.1111/j.1423-0410.1987.tb03007.x.
Abstract
Six different hybridoma cell lines were obtained producing IgM monoclonal antibodies (MAbs) against human blood group A antigen. All these MAbs agglutinate the A1, A1B and A2 erythrocytes, while only one of them agglutinates the A2B erythrocytes. The agglutination activity of 3 of these MAbs is inhibited by N-acetyl-D-galactosamine (D-GalNAc). Dissociation constants of complexes of these MAbs with D-GalNAc are approximately 2.2 X 10(-3) mol/l.
摘要
获得了六种不同的杂交瘤细胞系，它们产生针对人血型A抗原的IgM单克隆抗体（MAb）。所有这些单克隆抗体都能凝集A1、A1B和A2红细胞，而其中只有一种能凝集A2B红细胞。其中3种单克隆抗体的凝集活性被N-乙酰-D-半乳糖胺（D-GalNAc）抑制。这些单克隆抗体与D-GalNAc复合物的解离常数约为2.2×10^(-3) mol/l。
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