Teijeira Alvaro, Russo Erica, Halin Cornelia
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, HCI H413, 8093, Zurich, Switzerland.
Semin Immunopathol. 2014 Mar;36(2):261-74. doi: 10.1007/s00281-013-0410-8. Epub 2014 Jan 9.
In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses.
与白细胞通过血管的迁移不同,通过淋巴管(LVs)的运输特征则了解得少得多。通过这条途径迁移的一种重要细胞类型是抗原呈递树突状细胞(DCs),它对于诱导保护性免疫以及维持免疫耐受至关重要。在这篇综述中,我们将总结并讨论目前关于控制DC从皮肤向淋巴管迁移、进入淋巴管并在淋巴管内迁移,随后DC抵达引流淋巴结并在其中迁移的细胞和分子事件的知识。最后,我们将讨论治疗性靶向这一迁移步骤以调节免疫反应的潜在策略。