树突状细胞谱系：在稳态和炎症环境中树突状细胞及其亚群的发生和功能。
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
机构信息
Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA.
出版信息
Annu Rev Immunol. 2013;31:563-604. doi: 10.1146/annurev-immunol-020711-074950.
Abstract
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
摘要
树突状细胞（DCs）形成了一个显著的细胞网络，根据外周线索来塑造适应性免疫反应。经过四十年的研究，我们现在知道 DC 起源于与其他白细胞不同的造血谱系，确立了 DC 系统作为独特的造血分支。最近的工作还表明，组织 DC 由发育和功能不同的亚群组成，这些亚群可差异化调节 T 淋巴细胞功能。本综述讨论了我们对 DC 谱系定向、分化、多样化和原位功能调节的理解方面的主要进展。
相似文献
1
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.树突状细胞谱系：在稳态和炎症环境中树突状细胞及其亚群的发生和功能。
Annu Rev Immunol. 2013;31:563-604. doi: 10.1146/annurev-immunol-020711-074950.
2
Deciphering the transcriptional network of the dendritic cell lineage.解析树突状细胞谱系的转录网络。
Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.
3
GM-CSF alters dendritic cells in autoimmune diseases.GM-CSF 改变自身免疫性疾病中的树突状细胞。
Autoimmunity. 2013 Nov;46(7):409-18. doi: 10.3109/08916934.2013.803533. Epub 2013 Jun 21.
4
Origin and development of dendritic cells.树突状细胞的起源与发展。
Immunol Rev. 2010 Mar;234(1):45-54. doi: 10.1111/j.0105-2896.2009.00879.x.
5
Human dendritic cell subsets.人类树突状细胞亚群。
Immunology. 2013 Sep;140(1):22-30. doi: 10.1111/imm.12117.
6
The development and function of dendritic cell populations and their regulation by miRNAs.树突状细胞群体的发育、功能及其受微小RNA的调控
Protein Cell. 2017 Jul;8(7):501-513. doi: 10.1007/s13238-017-0398-2. Epub 2017 Mar 31.
7
A common pathway for dendritic cell and early B cell development.树突状细胞和早期B细胞发育的共同途径。
J Immunol. 2001 Aug 1;167(3):1387-92. doi: 10.4049/jimmunol.167.3.1387.
8
Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells.共刺激分子和免疫检查点在不同亚群的树突状细胞上呈差异性表达。
Front Immunol. 2019 Jun 11;10:1325. doi: 10.3389/fimmu.2019.01325. eCollection 2019.
9
Steady-state and inflammatory dendritic-cell development.稳态和炎症性树突状细胞的发育
Nat Rev Immunol. 2007 Jan;7(1):19-30. doi: 10.1038/nri1996. Epub 2006 Dec 15.
10
Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice.小鼠非淋巴组织树突状细胞的起源和功能异质性。
Immunol Rev. 2010 Mar;234(1):55-75. doi: 10.1111/j.0105-2896.2009.00885.x.
引用本文的文献
1
Precision nanotherapeutics for kidney disease: targeting inflammation and maladaptive repair.用于肾脏疾病的精准纳米疗法：靶向炎症和适应性不良修复
Int Urol Nephrol. 2025 Sep 3. doi: 10.1007/s11255-025-04714-9.
2
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): the interplay of gut microbiome, insulin resistance, and diabetes.代谢功能障碍相关脂肪性肝病（MASLD）：肠道微生物群、胰岛素抵抗和糖尿病之间的相互作用
Front Med (Lausanne). 2025 Aug 14;12:1618275. doi: 10.3389/fmed.2025.1618275. eCollection 2025.
3
Boosting Dendritic Cell Function in Cancer.增强癌症中树突状细胞的功能
Cancer Med. 2025 Sep;14(17):e71062. doi: 10.1002/cam4.71062.
4
Immune Responses of Dendritic Cells to Zoonotic DNA and RNA Viruses.树突状细胞对人畜共患DNA和RNA病毒的免疫反应
Vet Sci. 2025 Jul 24;12(8):692. doi: 10.3390/vetsci12080692.
5
PARP Inhibition Shifts Murine Myeloid Cells Toward a More Tolerogenic Profile In Vivo.PARP抑制在体内使小鼠骨髓细胞向更具耐受性的表型转变。
Biomolecules. 2025 Aug 9;15(8):1149. doi: 10.3390/biom15081149.
6
Langerhans cells drive Tfh and B cell responses independent of canonical cytokine signals.朗格汉斯细胞独立于经典细胞因子信号驱动滤泡辅助性T细胞和B细胞反应。
Front Immunol. 2025 Jul 18;16:1611812. doi: 10.3389/fimmu.2025.1611812. eCollection 2025.
7
Immunomodulatory Effects of Phage GADS24 on Human Dendritic Cells.噬菌体GADS24对人树突状细胞的免疫调节作用
Biomedicines. 2025 Jun 21;13(7):1519. doi: 10.3390/biomedicines13071519.
8
Myeloid cells in chronic liver inflammation.慢性肝脏炎症中的髓样细胞。
Cell Mol Immunol. 2025 Jul 28. doi: 10.1038/s41423-025-01324-4.
9
Understanding the probiotic health benefits of subsp. , BB-12™.了解亚种BB - 12™的益生菌健康益处。
Front Microbiol. 2025 Jul 2;16:1605044. doi: 10.3389/fmicb.2025.1605044. eCollection 2025.
10
MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.微小RNA调节肺泡巨噬细胞稳态及其在肺纤维化中的功能。
Front Immunol. 2025 Jun 23;16:1598306. doi: 10.3389/fimmu.2025.1598306. eCollection 2025.
本文引用的文献
1
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.基质细胞衍生的白细胞介素-34 控制朗格汉斯细胞的发育和维持以及小神经胶质细胞的维持。
Immunity. 2012 Dec 14;37(6):1050-1060. doi: 10.1016/j.immuni.2012.11.001. Epub 2012 Nov 21.
2
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.交叉呈递 CD103+树突状细胞可免受流感病毒感染。
J Clin Invest. 2012 Nov;122(11):4037-47. doi: 10.1172/JCI60659. Epub 2012 Oct 8.
3
Compensatory dendritic cell development mediated by BATF-IRF interactions.BATF-IRF 相互作用介导的补偿性树突状细胞发育。
Nature. 2012 Oct 25;490(7421):502-7. doi: 10.1038/nature11531. Epub 2012 Sep 19.
4
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.锌指转录因子 zDC 是一种负调控因子，需要其防止在静息状态下经典树突状细胞的激活。
J Exp Med. 2012 Aug 27;209(9):1583-93. doi: 10.1084/jem.20121003. Epub 2012 Jul 30.
5
Deciphering the transcriptional network of the dendritic cell lineage.解析树突状细胞谱系的转录网络。
Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.
6
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.人类组织中含有 CD141hi 交叉呈递树突状细胞，其功能与小鼠 CD103+ 非淋巴样树突状细胞具有同源性。
Immunity. 2012 Jul 27;37(1):60-73. doi: 10.1016/j.immuni.2012.04.012. Epub 2012 Jul 12.
7
Cross-presentation by dendritic cells.树突状细胞的交叉呈递。
Nat Rev Immunol. 2012 Jul 13;12(8):557-69. doi: 10.1038/nri3254.
8
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells.迁移而非淋巴组织驻留的树突状细胞通过诱导 iTreg 细胞来维持外周耐受和预防自身免疫。
Blood. 2012 Aug 9;120(6):1237-45. doi: 10.1182/blood-2011-09-379776. Epub 2012 Jul 3.
9
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.GM-CSF 控制非淋巴组织树突状细胞的稳态，但对于炎症性树突状细胞的分化不是必需的。
Immunity. 2012 Jun 29;36(6):1031-46. doi: 10.1016/j.immuni.2012.03.027.
10
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.IL-34 是 CSF1R 的组织限制性配体，对于朗格汉斯细胞和小神经胶质细胞的发育是必需的。
Nat Immunol. 2012 Jun 24;13(8):753-60. doi: 10.1038/ni.2360.
Zotero 插件