Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA.
Annu Rev Immunol. 2013;31:563-604. doi: 10.1146/annurev-immunol-020711-074950.
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
树突状细胞（DCs）形成了一个显著的细胞网络，根据外周线索来塑造适应性免疫反应。经过四十年的研究，我们现在知道 DC 起源于与其他白细胞不同的造血谱系，确立了 DC 系统作为独特的造血分支。最近的工作还表明，组织 DC 由发育和功能不同的亚群组成，这些亚群可差异化调节 T 淋巴细胞功能。本综述讨论了我们对 DC 谱系定向、分化、多样化和原位功能调节的理解方面的主要进展。
