Assem E S, Abdullah N A
Agents Actions. 1987 Apr;20(3-4):295-8. doi: 10.1007/BF02074695.
Antigen challenge of isolated perfused kidneys of sensitized guinea-pigs consistently released a large proportion of their histamine content, and caused a reduction in renal perfusate flow rate (RPFR) which could not simply be due to the released histamine, since much larger amounts of exogenous histamine were needed to produce a comparable effect. Reduction in RPFR by histamine was blocked by mepyramine but not by cimetidine, i.e. it is mediated by an H1-receptor mechanism.
对致敏豚鼠的离体灌注肾脏进行抗原激发，始终会释放出很大一部分组胺含量，并导致肾灌注液流速（RPFR）降低，而这一降低不能简单归因于释放出的组胺，因为需要大量得多的外源性组胺才能产生类似效果。组胺导致的RPFR降低可被美吡拉敏阻断，但不能被西咪替丁阻断，也就是说，它是由H1受体机制介导的。
