Pirotzky E, Hieblot C, Benveniste J, Laurent J, Lagrue G, Noirot C
Lancet. 1982 Feb 13;1(8268):358-61. doi: 10.1016/s0140-6736(82)91391-5.
The degranulation of basophils in the presence of a specific allergen (human basophil degranulation test, HBDT) is an index of IgE-dependent cellular response and it was tested in 46 unselected idiopathic nephrotic syndrome (INS) patients with or without atopic manifestations. 28 of the INS patients had "minimal change" nephrotic syndrome (MCNS) and 18 had focal segmental glomerular sclerosis (FSGS). 29 patients with different types of primary glomerulonephritis (GN) and 11 healthy donors acted as controls. The HBDT was positive in 16 (57%) of 28 MCNS and in 14 (77.8%) of 18 FSGS patients. Only 5 (17.2%) of 29 GN and 1 (6%) of 11 blood donors exhibited positive HBDT. House dust was the commonest allergen to which MCNS and FSGS subjects were sensitive, whereas sensitivity to grass pollen, moulds, and animal danders was less common. 8 MCNS and 8 FSGS subjects were sensitive to house dust plus another allergen. 4 MCNS and 1 FSGS patient had fewer than 5/microliters basophils; 4 of these 5 patients were having a relapse of their nephrotic syndrome at the time. The demonstration of enhanced IgE-basophil sensitisation in INS patients suggests than an anaphylactic process plays a part in the pathogenesis of INS.
在特定变应原存在的情况下嗜碱性粒细胞脱颗粒（人嗜碱性粒细胞脱颗粒试验，HBDT）是IgE依赖性细胞反应的一项指标，在46例未经挑选的有或无特应性表现的特发性肾病综合征（INS）患者中进行了检测。28例INS患者患有“微小病变”肾病综合征（MCNS），18例患有局灶节段性肾小球硬化（FSGS）。29例不同类型的原发性肾小球肾炎（GN）患者和11名健康供者作为对照。28例MCNS患者中有16例（57%）HBDT呈阳性，18例FSGS患者中有14例（77.8%）呈阳性。29例GN患者中只有5例（17.2%）和11名献血者中有1例（6%）HBDT呈阳性。屋尘是MCNS和FSGS患者最常见的敏感变应原，而对草花粉、霉菌和动物皮屑敏感则较少见。8例MCNS患者和8例FSGS患者对屋尘加另一种变应原敏感。4例MCNS患者和1例FSGS患者的嗜碱性粒细胞少于5/微升；这5例患者中有4例当时肾病综合征复发。INS患者中IgE-嗜碱性粒细胞致敏增强的证明提示过敏反应过程在INS的发病机制中起作用。
