Barth H, Giertz H, Schmal A, Lorenz W
Agents Actions. 1987 Apr;20(3-4):310-3. doi: 10.1007/BF02074699.
After an i.v. application of 100 mg tramadol in 13 healthy volunteers no change in plasma histamine concentration could be detected,( systemic anaphylactoid reactions did not occur, cutaneous reactions were not rated as anaphylactoid since itching and erythema were seen only once after tramadol whereas erythema was also observed twice after saline, blood pressure and heart rate were only very slightly and transiently elevated without any abnormalities in ECG-readings and only side effects typical for opioid therapy were observed.
在13名健康志愿者静脉注射100毫克曲马多后，未检测到血浆组胺浓度变化，（未发生全身性类过敏反应，皮肤反应未被评定为类过敏反应，因为曲马多给药后仅出现过一次瘙痒和红斑，而生理盐水给药后也出现过两次红斑，血压和心率仅轻微且短暂升高，心电图读数无任何异常，仅观察到阿片类药物治疗的典型副作用。
