• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Rapid resistome fingerprinting and clonal lineage profiling of carbapenem-resistant Klebsiella pneumoniae isolates by targeted next-generation sequencing.通过靶向新一代测序对耐碳青霉烯类肺炎克雷伯菌分离株进行快速耐药基因组指纹图谱分析和克隆谱系分析。
J Clin Microbiol. 2014 Mar;52(3):987-90. doi: 10.1128/JCM.03247-13. Epub 2014 Jan 8.
2
Multiclonal emergence of carbapenem-resistant Klebsiella pneumoniae in Tuscany, Italy.意大利托斯卡纳地区耐碳青霉烯类肺炎克雷伯菌的多克隆出现。
Int J Antimicrob Agents. 2010 Dec;36(6):576-8. doi: 10.1016/j.ijantimicag.2010.08.004. Epub 2010 Sep 24.
3
Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital.在一家三级医院引起感染的肺炎克雷伯菌ST101碳青霉烯耐药和碳青霉烯敏感同基因分离株。
BMC Microbiol. 2015 Sep 3;15:177. doi: 10.1186/s12866-015-0510-9.
4
Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012-2014.2012 - 2014年在意大利ASST Fatebenefratelli Sacco医院分离的耐碳青霉烯类肺炎克雷伯菌菌株的全基因组测序用于分子特征分析
BMC Infect Dis. 2017 Oct 10;17(1):666. doi: 10.1186/s12879-017-2760-7.
5
Co-existence of virulence factors and antibiotic resistance in new Klebsiella pneumoniae clones emerging in south of Italy.新克氏肺炎克隆在意大利南部出现，其毒力因子与抗生素耐药性共存。
BMC Infect Dis. 2019 Nov 4;19(1):928. doi: 10.1186/s12879-019-4565-3.
6
Clonal diversity and genetic profiling of antibiotic resistance among multidrug/carbapenem-resistant Klebsiella pneumoniae isolates from a tertiary care hospital in Saudi Arabia.沙特阿拉伯一家三级护理医院耐多药/碳青霉烯类耐药肺炎克雷伯菌分离株的抗生素耐药克隆多样性和基因谱分析。
BMC Infect Dis. 2018 May 3;18(1):205. doi: 10.1186/s12879-018-3114-9.
7
Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China.中国重庆分离的耐碳青霉烯类肺炎克雷伯菌菌株的多重耐药机制
Ann Lab Med. 2017 Sep;37(5):398-407. doi: 10.3343/alm.2017.37.5.398.
8
The mechanism of high-level carbapenem resistance in Klebsiella pneumoniae: underlying Ompk36-deficient strains represent a threat of emerging high-level carbapenem-resistant K. pneumoniae with IMP-1 β-lactamase production in Japan.高产碳青霉烯类耐药肺炎克雷伯菌的机制：产 IMP-1 型β-内酰胺酶的 OmpK36 缺陷株代表了日本高产碳青霉烯类耐药肺炎克雷伯菌的新威胁。
Microb Drug Resist. 2013 Aug;19(4):274-81. doi: 10.1089/mdr.2012.0248. Epub 2013 Mar 20.
9
Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae, São Paulo, Brazil.巴西圣保罗耐碳青霉烯类肺炎克雷伯菌中的多粘菌素B耐药性
Emerg Infect Dis. 2016 Oct;22(10):1849-51. doi: 10.3201/eid2210.160695.
10
Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea.韩国碳青霉烯类耐药肠杆菌科分离株的特征。
Diagn Microbiol Infect Dis. 2013 Aug;76(4):486-90. doi: 10.1016/j.diagmicrobio.2013.04.006. Epub 2013 May 18.

引用本文的文献

1
From Panels to Pathogen Networks: The Expanding Role of Targeted Sequencing in Veterinary Medicine.从检测板到病原体网络：靶向测序在兽医学中不断扩大的作用
Biology (Basel). 2025 Aug 18;14(8):1075. doi: 10.3390/biology14081075.
2
Evaluation of an Accelerated Workflow for Surveillance of ESBL (CTX-M)-Producing Escherichia coli Using Amplicon-Based Next-Generation Sequencing and Automated Analysis.使用基于扩增子的下一代测序和自动化分析对产超广谱β-内酰胺酶（CTX-M）的大肠杆菌进行监测的加速工作流程评估。
Microorganisms. 2018 Jan 11;6(1):6. doi: 10.3390/microorganisms6010006.
3
Whole-genome sequencing of Klebsiella pneumoniae MDR strain isolated in a Syrian refugee.对一名叙利亚难民中分离出的肺炎克雷伯菌多重耐药菌株进行全基因组测序。
Pathog Glob Health. 2017 Jun;111(4):212-215. doi: 10.1080/20477724.2017.1316918. Epub 2017 Apr 12.
4
Direct detection and prediction of all pneumococcal serogroups by target enrichment-based next-generation sequencing.基于靶向富集的新一代测序技术直接检测和预测所有肺炎球菌血清群。
J Clin Microbiol. 2014 Dec;52(12):4244-52. doi: 10.1128/JCM.02397-14. Epub 2014 Oct 1.
5
Next-generation sequencing for typing and detection of resistance genes: performance of a new commercial method during an outbreak of extended-spectrum-beta-lactamase-producing Escherichia coli.用于耐药基因分型和检测的新一代测序技术：一种新型商业方法在产超广谱β-内酰胺酶大肠杆菌暴发期间的性能表现
J Clin Microbiol. 2014 Jul;52(7):2454-60. doi: 10.1128/JCM.00313-14. Epub 2014 Apr 30.
6
The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening.通过全基因组下一代测序诊断传染病：一个新时代正在开启。
Front Cell Infect Microbiol. 2014 Mar 6;4:25. doi: 10.3389/fcimb.2014.00025. eCollection 2014.

本文引用的文献

1
Large oligoclonal outbreak due to Klebsiella pneumoniae ST14 and ST26 producing the FOX-7 AmpC β-lactamase in a neonatal intensive care unit.新生儿重症监护病房中由产FOX-7 AmpC β-内酰胺酶的肺炎克雷伯菌ST14和ST26引起的大规模寡克隆暴发。
J Clin Microbiol. 2013 Dec;51(12):4067-72. doi: 10.1128/JCM.01982-13. Epub 2013 Oct 2.
2
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.全球扩展型碳青霉烯酶肺炎克雷伯菌的临床流行病学。
Lancet Infect Dis. 2013 Sep;13(9):785-96. doi: 10.1016/S1473-3099(13)70190-7.
3
Rapid bacterial whole-genome sequencing to enhance diagnostic and public health microbiology.快速的细菌全基因组测序以增强诊断和公共卫生微生物学。
JAMA Intern Med. 2013 Aug 12;173(15):1397-404. doi: 10.1001/jamainternmed.2013.7734.
4
Progress on the development of rapid methods for antimicrobial susceptibility testing.抗菌药物敏感性快速检测方法的研发进展
J Antimicrob Chemother. 2013 Dec;68(12):2710-7. doi: 10.1093/jac/dkt253. Epub 2013 Jun 30.
5
Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011.意大利产 KPC 碳青霉烯酶肺炎克雷伯菌的流行扩散：2011 年 5 月 15 日至 6 月 30 日首次全国调查结果。
Euro Surveill. 2013 May 30;18(22):20489.
6
Bacteraemia due to OXA-48-carbapenemase-producing Enterobacteriaceae: a major clinical challenge.产 OXA-48 碳青霉烯酶肠杆菌科细菌导致的菌血症：主要临床挑战。
Clin Microbiol Infect. 2013 Feb;19(2):E72-9. doi: 10.1111/1469-0691.12091. Epub 2012 Dec 12.
7
Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.肺炎克雷伯菌和其他肠杆菌科细菌中的碳青霉烯酶：具有全球范围的不断演变的危机。
Clin Microbiol Rev. 2012 Oct;25(4):682-707. doi: 10.1128/CMR.05035-11.
8
Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing.应用全基因组测序追踪医院碳青霉烯类耐药肺炎克雷伯菌暴发疫情
Sci Transl Med. 2012 Aug 22;4(148):148ra116. doi: 10.1126/scitranslmed.3004129.
9
Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak.应用全基因组快速测序调查新生儿耐甲氧西林金黄色葡萄球菌爆发疫情
N Engl J Med. 2012 Jun 14;366(24):2267-75. doi: 10.1056/NEJMoa1109910.
10
Identification and screening of carbapenemase-producing Enterobacteriaceae.碳青霉烯酶肠杆菌科的鉴定和筛选。
Clin Microbiol Infect. 2012 May;18(5):432-8. doi: 10.1111/j.1469-0691.2012.03815.x.

通过靶向新一代测序对耐碳青霉烯类肺炎克雷伯菌分离株进行快速耐药基因组指纹图谱分析和克隆谱系分析。

Rapid resistome fingerprinting and clonal lineage profiling of carbapenem-resistant Klebsiella pneumoniae isolates by targeted next-generation sequencing.

作者信息

Arena Fabio, Rolfe P Alexander, Doran Graeme, Conte Viola, Gruszka Sarah, Clarke Thomas, Adesokan Yemi, Giani Tommaso, Rossolini Gian Maria

机构信息

Department of Medical Biotechnologies, University of Siena, Siena, Italy.

出版信息

J Clin Microbiol. 2014 Mar;52(3):987-90. doi: 10.1128/JCM.03247-13. Epub 2014 Jan 8.

DOI:10.1128/JCM.03247-13
PMID:24403299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3957740/
Abstract

Thirty-two carbapenem-resistant Klebsiella pneumoniae isolates, representative of different resistance mechanisms and clonal lineages, were analyzed with the Pathogenica HAI BioDetection system, based on targeted next-generation sequencing (NGS) technology. With most strains, the system simultaneously yielded comprehensive information on relevant β-lactam resistance determinants and accurate discrimination of clonal lineages, in a shorter time frame and in a less labor-intensive manner than currently available methods for molecular epidemiology analysis. Results supported the usefulness of targeted NGS-based technologies for similar applications.

摘要

基于靶向新一代测序（NGS）技术，使用Pathogenica HAI生物检测系统对32株耐碳青霉烯类肺炎克雷伯菌分离株进行了分析，这些分离株代表了不同的耐药机制和克隆谱系。对于大多数菌株，该系统能在更短的时间内，以比目前分子流行病学分析方法更低的劳动强度，同时提供有关相关β-内酰胺耐药决定因素的全面信息，并准确区分克隆谱系。结果支持了基于靶向NGS的技术在类似应用中的实用性。