Service de Bactériologie-Virologie, INSERM U914 'Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France.
Clin Microbiol Infect. 2012 May;18(5):432-8. doi: 10.1111/j.1469-0691.2012.03815.x.
Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.
碳青霉烯水解β-内酰胺酶是最强大的β-内酰胺酶，能够几乎水解所有β-内酰胺类抗生素。它们主要有 KPC、VIM、IMP、NDM 和 OXA-48 型。目前，肠杆菌科中这些碳青霉烯酶的广泛传播是一个令人关注的重要来源，因为这些碳青霉烯酶的产生者具有多药耐药性。对感染患者和携带者的检测是防止其传播的两种主要方法。表型和基于分子的技术能够识别这些碳青霉烯酶的产生者，尽管效率有所不同。携带者的检测仍然主要依赖于筛选培养基的使用。
