Yamazaki M
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 2):2083-8.
Endogenous protein factors such as animal lectins and fibrin are able to induce a cytotoxin from murine peritoneal macrophages. Cytotoxins were also induced from immature macrophages in bone marrow and polymorphonuclear leukocytes. These three cytotoxins differed in their releasing mechanisms, but they showed common antigenicity. TNF was chemotactic for polymorphonuclear leukocytes. Therefore, the antitumor effects of cytotoxins may include the participation of normal cells as well as their direct cytotoxicity.
内源性蛋白质因子，如动物凝集素和纤维蛋白，能够诱导小鼠腹腔巨噬细胞产生一种细胞毒素。骨髓中的未成熟巨噬细胞和多形核白细胞也能产生细胞毒素。这三种细胞毒素的释放机制不同，但它们具有共同的抗原性。肿瘤坏死因子对多形核白细胞具有趋化作用。因此，细胞毒素的抗肿瘤作用可能包括正常细胞的参与以及它们的直接细胞毒性。
