[大鼠肥大细胞与分子氧的刺激]
[Stimulation of rat mastocytes and molecular oxygen].
作者信息
Lagneaux D, Lecomte J, Damas J
出版信息
Arch Int Physiol Biochim. 1986 Dec;94(5):S39-42.
Free peritoneal mast-cells of the rat are stimulated in vitro by molecular oxygen as well as by hydrogen peroxide. Histamine release is also observed in vivo when molecular oxygen or diluted solutions of hydrogen peroxide are injected into the peritoneal cavity of the rat. Inflammatory lesions are produced (vascular congestion, oedema, exudate) which are suppressed by pretreatment with anti-H1 antihistaminics. When hydrogen peroxide solutions are more concentrated, inflammation is also provoked but antihistaminics are no more inhibitory. Mast-cells of the skin and of the lungs are not stimulated neither by molecular oxygen, nor by hydrogen peroxide.
大鼠的游离腹膜肥大细胞在体外可被分子氧以及过氧化氢刺激。当将分子氧或过氧化氢稀释溶液注入大鼠腹腔时，体内也会观察到组胺释放。会产生炎症病变（血管充血、水肿、渗出液），而用抗H1抗组胺药预处理可抑制这些病变。当过氧化氢溶液浓度更高时，也会引发炎症，但抗组胺药不再具有抑制作用。皮肤和肺部的肥大细胞既不会被分子氧刺激，也不会被过氧化氢刺激。
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