一名患有高同型半胱氨酸血症和高γ球蛋白血症的囊性纤维化患者出现双侧视网膜中央静脉阻塞。
Sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia.
作者信息
Gelman Rony, DiMango Emily A, Schiff William M
机构信息
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, CA ; Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY.
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
出版信息
Retin Cases Brief Rep. 2013 Fall;7(4):362-7. doi: 10.1097/ICB.0b013e3182965271.
PURPOSE
To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up.
METHODS
Observational case report of one patient.
RESULTS
A 31 year-old male with a history of cystic fibrosis presented with a central retinal vein occlusion (CRVO) in his left eye, followed by a CRVO in his right eye 4 years later. His medical workup was significant for elevated levels of homocysteine and gamma-globulins, which coincided with initiation of intravenous immunoglobulin (IVIG) proceeding his second CRVO.
CONCLUSIONS
We describe a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up and discuss the important role of these risk factors in retinal venous occlusive disease.
目的
报告一例囊性纤维化患者在6年随访期间先后发生双侧视网膜中央静脉阻塞，该患者同时伴有高同型半胱氨酸血症和高γ球蛋白血症。
方法
对一名患者进行观察性病例报告。
结果
一名有囊性纤维化病史的31岁男性，左眼出现视网膜中央静脉阻塞（CRVO），4年后右眼也出现CRVO。其医学检查显示同型半胱氨酸和γ球蛋白水平升高，这与他第二次CRVO之前开始静脉注射免疫球蛋白（IVIG）的时间相吻合。
结论
我们描述了一例囊性纤维化患者在6年随访期间先后发生双侧视网膜中央静脉阻塞，该患者伴有高同型半胱氨酸血症和高γ球蛋白血症，并讨论了这些危险因素在视网膜静脉阻塞性疾病中的重要作用。
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