Moghimi Sasan, Najmi Zahra, Faghihi Hooshang, Karkhaneh Reza, Farahvash Mohammad Sadegh, Maghsoudipour Maryam
Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Quazvin Square, Tehran 1336616351, Iran.
Int Ophthalmol. 2008 Feb;28(1):23-8. doi: 10.1007/s10792-007-9103-4. Epub 2007 Jul 17.
To evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (CRVO) in the Iranian population and determine whether hyperhomocysteinemia is also a risk factor for CRVO.
Fifty-four patients with recently diagnosed CRVO were studied. Their fasting total plasma homocysteine level was compared with a matched control group of 51 patients evaluated in the same clinic for a non-retinal disease diagnosis.
The mean total plasma homocysteine level was 14.76+/-7.67 micromol/l in cases, and 11.42+/-3.74 micromol/l in control subjects. It showed a significant difference (P=0.005) in mean plasma homocysteine level between cases and control group. Odds ratio of CRVO for individuals with hyperhomocysteinemia was 2.88 (95% CI=1.08-7.71 and P=0.03). The overall multivariable-adjusted odds of CRVO in participants with plasma homocysteine level above 15 micromol/l was 4.71 (95% CI=1.46-15.19 and P=0.009) Hyperhomocysteinemia was not statistically different in each age group (<60 years: 27%, 61-70 years: 33.3%, 71-80 years: 31.6%, >81 years: 33.3%, Chi-square test, P=0.98).
Elevated total plasma homocysteine level is an independent risk factor for CRVO in Iranian population. In addition to an evaluation of all conventional cardiovascular risk factors, measurement of total homocysteine for evidence of hyperhomocysteinemia may be important in the initial investigation and management of patients with CRVO.
评估伊朗人群视网膜中央静脉阻塞（CRVO）急性期的血浆总同型半胱氨酸水平，并确定高同型半胱氨酸血症是否也是CRVO的危险因素。
对54例近期诊断为CRVO的患者进行研究。将他们的空腹血浆总同型半胱氨酸水平与在同一诊所因非视网膜疾病诊断而评估的51例匹配对照组患者进行比较。
病例组的平均血浆总同型半胱氨酸水平为14.76±7.67微摩尔/升，对照组为11.42±3.74微摩尔/升。病例组与对照组之间的平均血浆同型半胱氨酸水平存在显著差异（P = 0.005）。高同型半胱氨酸血症个体患CRVO的比值比为2.88（95%可信区间=1.08 - 7.71，P = 0.03）。血浆同型半胱氨酸水平高于15微摩尔/升的参与者中，CRVO的总体多变量调整比值比为4.71（95%可信区间=1.46 - 15.19，P = 0.009）。各年龄组的高同型半胱氨酸血症无统计学差异（<60岁：27%，61 - 70岁：33.3%，71 - 80岁：31.6%，>81岁：33.3%，卡方检验，P = 0.98）。
血浆总同型半胱氨酸水平升高是伊朗人群CRVO的独立危险因素。除了评估所有传统心血管危险因素外，检测总同型半胱氨酸以确定高同型半胱氨酸血症的证据，在CRVO患者的初始调查和管理中可能很重要。
