Tassew Worku Chekol, Woldie Samson Sisay, Ferede Yeshiwas Ayale, Zeleke Agerie Mengistie, Nigussie Adane
Department of Medical Nursing, Teda Health Science College, Gondar, Ethiopia.
Department of Reproductive Health, Teda Health Science College, Gondar, Ethiopia.
BMC Cardiovasc Disord. 2025 May 15;25(1):367. doi: 10.1186/s12872-025-04808-3.
Dyslipidemia and other CVD risk factors in cardiac patients can lead to accelerated atherosclerosis, morbidity, and significant mortality. Identifying the potential contributory factors of dyslipidemia in hypertensive patients is crucial in order to manage the disease condition and reduce further complications. Although dyslipidemia has been studied in many countries, evidence of pooled prevalence and its risk factors in Ethiopia remains scarce. Thus, this meta-analysis aimed to estimate the pooled prevalence of dyslipidemia (high TG, low HDL-C, high LDL-C, and high TC) and associated factors among adults with hypertension in Ethiopia.
The reporting system adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines. Articles were searched using electronic databases such as PubMed, Cochrane Library, Science Direct, African Journals Online, and Google Scholar from April 1 to April 21, 2024 to find relevant studies. We utilized Endnote X7 and STATA 11 for bibliographical management and statistical analysis, respectively. The heterogeneity of the included studies was analyzed using forest plots, Cochran's Q statistics, I² test, and P-values.
The electronic searches yielded 10,629 articles. Based on the quality assessment, all the included studies had high quality. The overall pooled prevalence of dyslipidemia among hypertensive patients in Ethiopia was 37.12% (95% CI: 31.79-42.44%; I²=98.4%). The pooled point estimates for high TC were (33.39%, 95% CI: 23.92-42.85; I²=97.9%), TG (38.89%, 95% CI: 32.90-44.88; I²=93.6%), high LDL-c (33.98%, 95% CI: 21.46-46.49; I²=98.4%), and low HDL-c (42.23%, 95% CI: 28.76-55.71; I²=98.9%). Based on this meta-analysis, dyslipidemia was associated with age ≥ 40 years and sedentary lifestyle.
This study suggests that dyslipidemia was high among the study participants, which underlines urgent need for early detection and public health interventions through the integrated involvement of public, governmental, and non-governmental organizations. Dyslipidemia was associated with, age ≥ 40 years, and sedentary lifestyle. This alarms the need for lipid profile assessment for patients periodically, with treatment follow-up to monitor any rising patterns and cardiovascular related risks.
心脏病患者的血脂异常和其他心血管疾病风险因素可导致动脉粥样硬化加速、发病和显著死亡率。识别高血压患者血脂异常的潜在促成因素对于控制病情和减少进一步并发症至关重要。尽管许多国家都对血脂异常进行了研究，但埃塞俄比亚血脂异常的合并患病率及其风险因素的证据仍然很少。因此，本荟萃分析旨在估计埃塞俄比亚高血压成年人血脂异常（高甘油三酯、低高密度脂蛋白胆固醇、高低密度脂蛋白胆固醇和高总胆固醇）的合并患病率及其相关因素。
报告系统遵循系统评价和荟萃分析的首选报告项目指南。于2024年4月1日至4月21日使用电子数据库（如PubMed、Cochrane图书馆、Science Direct、非洲期刊在线和谷歌学术）搜索文章，以查找相关研究。我们分别使用Endnote X7和STATA 11进行文献管理和统计分析。使用森林图、 Cochr an Q统计量、I²检验和P值分析纳入研究的异质性。
电子检索共获得10629篇文章。基于质量评估，所有纳入研究的质量都很高。埃塞俄比亚高血压患者血脂异常的总体合并患病率为37.12%（95%CI：31.79 - 42.44%；I² = 98.4%）。高总胆固醇的合并点估计值为（33.39%，95%CI：23.92 - 42.85；I² = 97.9%），甘油三酯为（38.89%，95%CI：32.90 - 44.88；I² = 93.6%），高低密度脂蛋白胆固醇为（33.98%，95%CI：21.46 - 46.49；I² = 98.4%），低高密度脂蛋白胆固醇为（42.23%，95%CI：28.76 - 55.71；I² = 98.9%）。基于此荟萃分析，血脂异常与年龄≥40岁和久坐不动的生活方式有关。
本研究表明，研究参与者中血脂异常的发生率很高，这突出表明迫切需要通过公共、政府和非政府组织的综合参与进行早期检测和公共卫生干预。血脂异常与年龄≥40岁和久坐不动的生活方式有关。这提醒需要定期对患者进行血脂谱评估，并进行治疗随访，以监测任何上升趋势和心血管相关风险。
