Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
Diabetes Metab J. 2012 Feb;36(1):43-55. doi: 10.4093/dmj.2012.36.1.43. Epub 2012 Feb 17.
Dyslipidemia is a disorder of lipid metabolism, including elevated total cholesterol, elevated triglyceride, elevated low density lipoprotein cholesterol (LDL-C), and decreased high density lipoprotein cholesterol (HDL-C). The objective of this study was to investigate recent changes in the prevalence of dyslipidemia and also the rates of awareness, treatment, and control of dyslipidemia among Korean adults.
Dyslipidemia is defined according to the National Cholesterol Education Program-Adult Treatment Panel III as total cholesterol ≥240 mg/dL, LDL-C ≥160 mg/dL, HDL-C <40 mg/dL, and triglyceride ≥200 mg/dL. The prevalence of dyslipidemia was estimated for adults aged ≥20 years using the Korea National Health and Nutrition Survey (KNHANES) in 1998 (n=6,923), 2001 (n=4,882), and 2005 (n=5,323). Rates of awareness, treatment and control of dyslipidemia were calculated for adults aged ≥30 years using the KNHANES in 2005 (n=4,654).
The prevalence of dyslipidemia (aged ≥20 years) increased from 32.4% in 1998 to 42.6% in 2001 and 44.1% in 2005. Compared with the KNHANES in 1998, the prevalence of dyslipidemia was 47% (95% confidence interval [CI], 35% to 59%) higher in 2001 and 61% (95% CI, 49% to 75%) higher in 2005. In 2005, only 9.5% of people with dyslipidemia were aware of the disease, 5.2% used lipid-lowering medication, and 33.2% of patients with treatment reached treatment goals.
The prevalence of dyslipidemia in Korea gradually increased between 1998 and 2005. These findings suggest that more intense efforts for the prevention and treatment of dyslipidemia may lead to further improvement in the management of dyslipidemia.
血脂异常是一种脂代谢紊乱,包括总胆固醇升高、甘油三酯升高、低密度脂蛋白胆固醇升高(LDL-C)和高密度脂蛋白胆固醇降低(HDL-C)。本研究旨在调查韩国成年人血脂异常的近期变化,以及血脂异常的知晓率、治疗率和控制率。
血脂异常根据国家胆固醇教育计划成人治疗专家组 III 标准定义为总胆固醇≥240mg/dL、LDL-C≥160mg/dL、HDL-C<40mg/dL 和甘油三酯≥200mg/dL。使用 1998 年(n=6923)、2001 年(n=4882)和 2005 年(n=5323)韩国国家健康和营养调查(KNHANES)的数据,估计≥20 岁成年人的血脂异常患病率。使用 2005 年(n=4654)KNHANES 数据,计算≥30 岁成年人血脂异常的知晓率、治疗率和控制率。
血脂异常(≥20 岁)的患病率从 1998 年的 32.4%上升至 2001 年的 42.6%和 2005 年的 44.1%。与 1998 年的 KNHANES 相比,2001 年血脂异常的患病率增加了 47%(95%置信区间[CI]:35%至 59%),2005 年增加了 61%(95% CI:49%至 75%)。2005 年,仅有 9.5%的血脂异常患者知晓该疾病,5.2%使用降脂药物,治疗的患者中有 33.2%达到了治疗目标。
1998 年至 2005 年间,韩国血脂异常的患病率逐渐增加。这些发现表明,加强血脂异常的预防和治疗工作可能会进一步改善血脂异常的管理。