Department of Dental Hygiene, College of Health Science, Gachon University, Incheon, South Korea.
School of Nursing, Hanyang University, Seoul, South Korea.
Clin Oral Investig. 2020 Feb;24(2):937-944. doi: 10.1007/s00784-019-02989-8. Epub 2019 Jul 2.
The aim of this study was to examine whether dyslipidemia is associated with periodontitis according to age, sex, smoking, and harmful alcohol use in a representative sample of Korean adults who participated in the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3).
We examined 3987 subjects aged 19 to 79 years who participated in the KNHANES VI-3. Dyslipidemia was defined according to the definition proposed by the Korean Society of Lipidology and Atherosclerosis. The periodontal status of the patients was assessed using the community periodontal index. Multivariate logistic regression analysis was carried out and adjusted for sociodemographic variables, oral and general health behaviors, and oral health status. All analyses considered a complex sampling design, and multivariate analysis was performed in the age, sex, smoking, and harmful alcohol use subgroups.
Multivariate logistic regression analysis revealed significant associations between periodontitis and dyslipidemia including hypertriglyceridemia and hypo-high-density lipoprotein (HDL) cholesterolemia. In the subgroup analysis, periodontitis was significantly associated with hypo-HDL cholesterolemia in subjects older than 40 years, males, heavy smokers, and hazardous and harmful alcohol users. Moreover, periodontitis was significantly associated with hypercholesterolemia in hazardous and harmful alcohol users.
The prevalence of periodontitis (CPI 3, 20.7%; CPI 4, 9.0%) was 29.7% in Korea. Hyper-TG and hypo-HDL-C were associated with periodontitis in all subjects. In the subgroup analysis, the association of periodontitis with hyper-TC and pre-hyper-TC was further confirmed in harmful alcohol users and males, respectively.
This study reaffirmed that periodontitis is associated with dyslipidemia, especially with hyper-TG and hypo-HDL-C. As the association of periodontitis with hypo-HDL-C, hyper-TC, and pre-hyper-TC was found differently in subgroups according to age, gender, smoking, and alcohol drinking, researchers need to consider effect modifiers in further studies on the association between periodontitis and dyslipidemia.
本研究旨在探讨在参加第六届韩国国家健康和营养检查调查（KNHANES VI-3）的代表性韩国成年人样本中，根据年龄、性别、吸烟和有害饮酒情况，血脂异常与牙周炎之间的关联。
我们检查了 3987 名年龄在 19 至 79 岁之间的参与者，这些参与者参加了 KNHANES VI-3。血脂异常根据韩国脂质和动脉粥样硬化学会提出的定义进行定义。患者的牙周状况使用社区牙周指数进行评估。进行了多变量逻辑回归分析，并调整了社会人口统计学变量、口腔和一般健康行为以及口腔健康状况。所有分析均考虑了复杂抽样设计，并在年龄、性别、吸烟和有害饮酒亚组中进行了多变量分析。
多变量逻辑回归分析显示，牙周炎与血脂异常（包括高三酰甘油血症和低高密度脂蛋白胆固醇血症）之间存在显著关联。在亚组分析中，在年龄大于 40 岁、男性、重度吸烟者和危险及有害饮酒者中，牙周炎与低高密度脂蛋白胆固醇血症显著相关。此外，在危险及有害饮酒者中，牙周炎与高胆固醇血症显著相关。
在韩国，牙周炎的患病率（CPI 3，20.7%；CPI 4，9.0%）为 29.7%。在所有受试者中，高 TG 和低 HDL-C 与牙周炎相关。在亚组分析中，在有害饮酒者和男性中，进一步证实了牙周炎与高 TC 和预高 TC 的关联。
本研究再次证实，牙周炎与血脂异常，尤其是与高三酰甘油血症和低高密度脂蛋白胆固醇血症有关。由于牙周炎与低高密度脂蛋白胆固醇、高 TC 和预高 TC 的关联在年龄、性别、吸烟和饮酒等亚组中存在差异，研究人员在进一步研究牙周炎与血脂异常之间的关联时需要考虑效应修饰因子。
