Andersson Morgan, Greiff Lennart, Ojeda Pedro, Wollmer Per
Department of Otorhinolaryngology, Skåne University Hospital , Sweden.
Curr Med Res Opin. 2014 Jun;30(6):1131-7. doi: 10.1185/03007995.2014.882299. Epub 2014 Jan 30.
Barrier-enforcing measures have been suggested as treatment options for allergic rhinitis. This review identifies and describes the literature on the subject.
Relevant publications were searched for in the PubMed database (search entries: 'allergic rhinitis' and 'treatment'). The evaluation comprised condition (seasonal or perennial allergic rhinitis), type of intervention, duration of treatment, study design, peer review status or not, number of test subjects, type of allergen exposure, and outcome in terms of effects or not on nasal symptoms of allergic rhinitis.
Fifteen studies were either identified in the PubMed database search or from the reference lists of identified publications. Seven were placebo-controlled, randomized, and peer-reviewed, and symptom-reducing effects were reported by all of these reports. Limitations of this review reflect that the remainder of the studies had inferior designs, particularly lack of placebo control.
Barrier-enforcing measures as achieved by nasal administrations of cellulose powder and microemulsions, respectively, have symptom-reducing effects in allergic rhinitis.
屏障强化措施已被提议作为变应性鼻炎的治疗选择。本综述对该主题的文献进行识别与描述。
在PubMed数据库中检索相关出版物（检索词：“变应性鼻炎”和“治疗”）。评估内容包括病情（季节性或常年性变应性鼻炎）、干预类型、治疗持续时间、研究设计、是否经过同行评审、受试对象数量、变应原暴露类型以及对变应性鼻炎鼻症状有无影响的结果。
在PubMed数据库检索或已识别出版物的参考文献列表中，共识别出15项研究。其中7项为安慰剂对照、随机且经过同行评审，所有这些报告均报道了症状减轻效果。本综述的局限性在于其余研究设计较差，尤其是缺乏安慰剂对照。
分别通过鼻腔给予纤维素粉和微乳剂实现的屏障强化措施对变应性鼻炎有症状减轻作用。
