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预测发生产科瘘的高危妇女:瘘管指数?两个队列的观察性研究比较。

Predicting women at risk for developing obstetric fistula: a fistula index? An observational study comparison of two cohorts.

机构信息

Selian Fistula Project, Arusha, Tanzania.

出版信息

BJOG. 2014 Apr;121(5):604-9. doi: 10.1111/1471-0528.12527. Epub 2014 Jan 10.

Abstract

OBJECTIVE

To ascertain if a predictor of obstructed labour and obstetric fistula (OF) occurrence could be devised.

DESIGN

Observational study of two cohorts.

SETTING

Selian Lutheran Mission Hospital, Arusha, Tanzania and Aberdeen Women's Centre, Freetown, Sierra Leone.

POPULATION

All women presenting with OF caused by obstructed labour and all women having a normal vaginal delivery (NVD) at both institutions were eligible for the study.

METHODS

All women with OF and those delivering normally had their height in centimetres measured and their intertuberous space measured by the number of examiner's knuckles admitted. The dimensions for OF and normal delivery were examined individually and multiplied to gain a 'fistula index'.

MAIN OUTCOMES MEASURES

Dimensions and index were compared statistically between OF and NVD women using t tests. Sensitivity, specificity and predictive values from receiver operating characteristic curves were obtained for predicting OF.

RESULTS

There were statistical differences between the groups with OF women being significantly shorter, having a smaller intertuberous space and lower fistula index than those undergoing NVD (each P < 0.001). Sensitivity was high for fistula index ≤ 507.5 (94.9%, 95% confidence interval 83.1-98.6%) and for intertuberous space of at least three knuckles (92.3%, 95% CI 79.7-97.3%) alone.

CONCLUSIONS

A simple antenatal measurement of intertuberous space could screen those women at higher risk of needing medical intervention to prevent OF.

摘要

目的

确定是否可以制定出预测难产和产科瘘(OF)发生的指标。

设计

对两个队列进行观察性研究。

地点

坦桑尼亚阿鲁沙的塞利安路德教会医院和塞拉利昂弗里敦的阿伯丁妇女中心。

人群

所有因难产导致 OF 的妇女以及在这两个机构正常阴道分娩(NVD)的妇女均有资格参加该研究。

方法

所有 OF 患者和正常分娩的妇女均测量其身高(厘米)和两坐骨结节间径(用检查者的指节数表示)。单独检查 OF 和正常分娩的尺寸,并相乘获得“瘘管指数”。

主要观察结果

使用 t 检验比较 OF 和 NVD 妇女的尺寸和指数。通过接收者操作特性曲线获得预测 OF 的灵敏度、特异性和预测值。

结果

OF 组与 NVD 组之间存在统计学差异,OF 组妇女明显更矮,两坐骨结节间径更小,瘘管指数更低(均 P < 0.001)。瘘管指数≤507.5 的灵敏度较高(94.9%,95%置信区间 83.1-98.6%),三指以上的两坐骨结节间径的灵敏度较高(92.3%,95%置信区间 79.7-97.3%)。

结论

简单的产前两坐骨结节间径测量可筛选出那些需要医疗干预以预防 OF 的高风险妇女。

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