Public Health Agency of Canada, Montreal, Canada.
Division of Gastroenterology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Gastroenterology. 2014 Apr;146(4):929-31. doi: 10.1053/j.gastro.2013.12.034. Epub 2014 Jan 7.
Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.
膳食中 ω6/ω3 多不饱和脂肪酸比例的增加与克罗恩病（CD）的发病机制有关，但流行病学数据有限。我们研究了控制多不饱和脂肪酸代谢的基因（CYP4F3、FADS1 和 FADS2）的变异，以及 ω6/ω3 的膳食比例是否会导致 CD 易感性。基于 182 名新诊断为 CD 的儿童和 250 名对照者的数据，我们发现如果 CYP4F3 和 FADS2 基因的特定变异携带者摄入更高的 ω6/ω3 膳食比例，他们更容易患 CD。我们的研究结果表明，饮食与基因的相互作用与 CD 的发病机制有关。
