在清醒大鼠中，甘丙肽通过生长激素释放因子（GRF）刺激生长激素（GH）分泌。
Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats.
作者信息
Murakami Y, Kato Y, Koshiyama H, Inoue T, Yanaihara N, Imura H
出版信息
Eur J Pharmacol. 1987 Apr 29;136(3):415-8. doi: 10.1016/0014-2999(87)90316-5.
The possibility of a role of hypothalamic growth hormone (GH)-releasing factor (GRF) in GH secretion induced by centrally administered galanin was investigated in freely moving male rats. Intracerebroventricular (i.c.v.) injection of synthetic galanin (0.4 or 2 micrograms/rat) elicited a dose-related increase in plasma GH in these conscious rats. Pretreatment with rabbit antiserum specific for rat GRF significantly inhibited the plasma GH increase induced by i.c.v. injection of galanin (2 micrograms/rat). These findings suggest that galanin-induced GH secretion in the rat is mediated at least in part by hypothalamic GRF.
在自由活动的雄性大鼠中，研究了下丘脑生长激素（GH）释放因子（GRF）在中枢给予甘丙肽诱导的GH分泌中所起作用的可能性。向清醒大鼠脑室内（i.c.v.）注射合成甘丙肽（0.4或2微克/只大鼠）可引起这些大鼠血浆GH呈剂量相关的增加。用对大鼠GRF特异的兔抗血清进行预处理，可显著抑制i.c.v.注射甘丙肽（2微克/只大鼠）所诱导的血浆GH增加。这些结果提示，大鼠中甘丙肽诱导的GH分泌至少部分是由下丘脑GRF介导的。
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