Bloch G, Neumann J M, Babin F, Huynh-Dinh T
FEBS Lett. 1987 Jul 27;219(2):464-8. doi: 10.1016/0014-5793(87)80273-9.
The RNA hexamer containing a 5-methyl cytosine (m5C) r(CGUAm5CG) was studied by 1H and 31P NMR at 500 MHz and 121 MHz, respectively. In contrast to r(CGm5CGCG) which exhibits an atypic duplex structure [(1987) J. Am. Chem. Soc. 109, 2539-2541], r(CGUAm5CG) adopts a classical A-type conformation. This result demonstrates that the influence of the m5C on the conformation of RNA hexamers is sequence-dependent.
分别在500兆赫和121兆赫下，通过1H和31P核磁共振对含有5-甲基胞嘧啶（m5C）的RNA六聚体r（CGUAm5CG）进行了研究。与呈现非典型双链结构的r（CGm5CGCG）[（1987年）《美国化学会志》109，2539 - 2541]不同，r（CGUAm5CG）采用经典的A型构象。这一结果表明，m5C对RNA六聚体构象的影响取决于序列。
