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1
NMR and CD studies on an oligonucleotide containing N4-methylcytosine.关于一种含有N4-甲基胞嘧啶的寡核苷酸的核磁共振和圆二色性研究。
Nucleic Acids Res. 1987 Mar 11;15(5):2191-201. doi: 10.1093/nar/15.5.2191.
2
NMR studies on oligodeoxyribonucleotides containing the dam methylation site GATC. Comparison between d(GGATCC) and d(GGm6ATCC).关于含有dam甲基化位点GATC的寡脱氧核糖核苷酸的核磁共振研究。d(GGATCC)与d(GGm6ATCC)的比较。
Biochemistry. 1985 Aug 13;24(17):4540-8. doi: 10.1021/bi00338a009.
3
The tetraribonucleotide rCpGpCpG forms a left-handed Z-RNA double-helix.四核糖核苷酸rCpGpCpG形成左手Z-RNA双螺旋。
Nucleic Acids Res. 1986 Feb 11;14(3):1279-91. doi: 10.1093/nar/14.3.1279.
4
Conformational analysis of r(CGCGCG) in aqueous solution: an A-type double helical conformation studied by two-dimensional nuclear Overhauser effect spectroscopy.水溶液中r(CGCGCG)的构象分析：通过二维核Overhauser效应光谱研究的A型双螺旋构象
Nucleic Acids Res. 1984 May 25;12(10):4323-38. doi: 10.1093/nar/12.10.4323.
5
Synthesis and physical characterization of DNA fragments containing N4-methylcytosine and 5-methylcytosine.含N4-甲基胞嘧啶和5-甲基胞嘧啶的DNA片段的合成与物理表征
Nucleic Acids Res. 1987 Oct 26;15(20):8467-78. doi: 10.1093/nar/15.20.8467.
6
Z helix-coil transition of d(C-Br8G-C-G-C-Br8G) studied by CD, 1H-NMR and IR spectroscopies.通过圆二色光谱、核磁共振氢谱和红外光谱研究d（C-Br8G-C-G-C-Br8G）的Z型螺旋-卷曲转变
J Biomol Struct Dyn. 1985 Jun;2(6):1185-203. doi: 10.1080/07391102.1985.10507632.
7
The B----Z transition in two synthetic oligonucleotides: d(C-2-amino-ACGTG) and d(m5CGCAm5CGTGCG) studied by IR, NMR and CD spectroscopies.通过红外光谱、核磁共振光谱和圆二色光谱研究的两种合成寡核苷酸：d(C-2-氨基-ACGTG) 和 d(m5CGCAm5CGTGCG) 中的B-Z转变
Nucleic Acids Res. 1984 Aug 10;12(15):6291-305. doi: 10.1093/nar/12.15.6291.
8
B,Z conformations and mechanism of the Z-B-coil transitions of the self-complementary deoxy-hexanucleotide d(C-G-m5C-G-C-G) by 1H-NMR and CD spectroscopy.通过氢核磁共振（1H-NMR）和圆二色光谱（CD）研究自互补脱氧六核苷酸d（C-G-m5C-G-C-G）的B、Z构象以及Z-B螺旋转变机制
J Biomol Struct Dyn. 1984 Jun;1(6):1347-71. doi: 10.1080/07391102.1984.10507525.
9
Sequence-dependence of the conformational changes induced by the 5-methyl cytosine in synthetic RNA oligomers.合成RNA寡聚物中5-甲基胞嘧啶诱导的构象变化的序列依赖性。
FEBS Lett. 1987 Jul 27;219(2):464-8. doi: 10.1016/0014-5793(87)80273-9.
10
Conformation of ribooligonucleotide duplexes containing an alternating C-G sequence which show an unusual circular dichroism spectrum.含有交替C-G序列的核糖寡核苷酸双链体的构象，其呈现出异常的圆二色光谱。
J Biol Chem. 1984 Feb 10;259(3):1390-3.

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Means, mechanisms and consequences of adenine methylation in DNA.DNA 中腺嘌呤甲基化的方式、机制和后果。
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A Deep Neural Network for Identifying DNA N4-Methylcytosine Sites.用于识别DNA N4-甲基胞嘧啶位点的深度神经网络
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Additive CHARMM force field for naturally occurring modified ribonucleotides.用于天然存在的修饰核糖核苷酸的加性CHARMM力场。
J Comput Chem. 2016 Apr 15;37(10):896-912. doi: 10.1002/jcc.24307. Epub 2016 Feb 3.
4
Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction.分子间“交叉扭矩”：由于沃森-克里克相互作用，N4-胞嘧啶炔丙基残基旋转至“CH”边缘。
Nucleic Acids Res. 2015 Jun 23;43(11):5275-83. doi: 10.1093/nar/gkv285. Epub 2015 Apr 30.
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Enzymatic synthesis of structure-free DNA with pseudo-complementary properties.具有假互补特性的无结构DNA的酶促合成。
Nucleic Acids Res. 2008 Jun;36(10):3409-19. doi: 10.1093/nar/gkn209. Epub 2008 Apr 29.
6
Elimination of band compression in sequencing gels by the use of N4-methyl-2'-deoxycytidine 5'-triphosphate.通过使用N4-甲基-2'-脱氧胞苷5'-三磷酸消除测序凝胶中的条带压缩。
Nucleic Acids Res. 1993 Jun 11;21(11):2709-14. doi: 10.1093/nar/21.11.2709.
7
The crystal structure of N4-methylcytosine.guanosine base-pairs in the synthetic hexanucleotide d(CGCGm4CG).合成六核苷酸d（CGCGm4CG）中N4-甲基胞嘧啶-鸟嘌呤碱基对的晶体结构
Nucleic Acids Res. 1993 Dec 11;21(24):5623-9. doi: 10.1093/nar/21.24.5623.
8
Synthesis and physical characterization of DNA fragments containing N4-methylcytosine and 5-methylcytosine.含N4-甲基胞嘧啶和5-甲基胞嘧啶的DNA片段的合成与物理表征
Nucleic Acids Res. 1987 Oct 26;15(20):8467-78. doi: 10.1093/nar/15.20.8467.
9
Synthesis of DNA fragments containing 5,6-dihydrothymine, a major product of thymine gamma radiolysis.
Nucleic Acids Res. 1988 Jan 11;16(1):319-26. doi: 10.1093/nar/16.1.319.

本文引用的文献

1
Molecular structure of (m5 dC-dG)3: the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA.（m5 dC-dG）3的分子结构：5-甲基胞嘧啶上的甲基在稳定Z-DNA中的作用。
Nucleic Acids Res. 1982 Dec 11;10(23):7879-92. doi: 10.1093/nar/10.23.7879.
2
Cytosine modification in DNA by BcnI methylase yields N4-methylcytosine.BcnI甲基化酶对DNA中的胞嘧啶进行修饰会产生N4-甲基胞嘧啶。
FEBS Lett. 1983 Sep 5;161(1):131-4. doi: 10.1016/0014-5793(83)80745-5.
3
Sequential resonance assignments in 1H NMR spectra of oligonucleotides by two-dimensional NMR spectroscopy.通过二维核磁共振光谱对寡核苷酸的1H NMR光谱进行顺序共振归属。
Biochemistry. 1984 Mar 27;23(7):1371-6. doi: 10.1021/bi00302a006.
4
Two-dimensional proton nuclear magnetic resonance investigation of the synthetic deoxyribonucleic acid decamer d(ATATCGATAT)2.合成脱氧核糖核酸十聚体d(ATATCGATAT)₂的二维质子核磁共振研究
Biochemistry. 1983 Dec 6;22(25):5943-51. doi: 10.1021/bi00294a038.
5
Nuclear Overhauser effect as a tool for the complete assignment of nonexchangeable proton resonances in short deoxyribonucleic acid helices.核Overhauser效应作为完全确定短脱氧核糖核酸螺旋中不可交换质子共振峰的一种工具。
Biochemistry. 1983 Oct 25;22(22):5194-200. doi: 10.1021/bi00291a020.
6
A thermally driven interconversion of B and Z-dna.B型和Z型DNA的热驱动相互转换
Biochem Biophys Res Commun. 1983 Aug 30;115(1):100-5. doi: 10.1016/0006-291x(83)90974-9.
7
Helix opening in deoxyribonucleic acid from a proton nuclear magnetic resonance study of imino and amino protons in d(CG)3.通过对d(CG)3中亚氨基和氨基质子的质子核磁共振研究得出的脱氧核糖核酸中的螺旋开口
Nucleic Acids Res. 1984 Nov 12;12(21):8269-79. doi: 10.1093/nar/12.21.8269.
8
The amino 1H resonances of oligonucleotide helices: d(CGCG).寡核苷酸螺旋的氨基 1H 共振：d(CGCG)
J Biomol Struct Dyn. 1984 Jun;1(6):1407-21. doi: 10.1080/07391102.1984.10507528.
9
Assignment of the non-exchangeable proton resonances of d(C-G-C-G-A-A-T-T-C-G-C-G) using two-dimensional nuclear magnetic resonance methods.使用二维核磁共振方法对d（C-G-C-G-A-A-T-T-C-G-C-G）的非交换质子共振进行归属
J Mol Biol. 1983 Dec 15;171(3):319-36. doi: 10.1016/0022-2836(83)90096-7.
10
Conformational stability of alternating d (CG) oligomers in high salt solution.交替的d（CG）寡聚物在高盐溶液中的构象稳定性。
Nucleic Acids Res. 1981 May 11;9(9):2195-206. doi: 10.1093/nar/9.9.2195.

关于一种含有N4-甲基胞嘧啶的寡核苷酸的核磁共振和圆二色性研究。

NMR and CD studies on an oligonucleotide containing N4-methylcytosine.

作者信息

Fazakerley G V, Kraszewski A, Téoule R, Guschlbauer W

出版信息

Nucleic Acids Res. 1987 Mar 11;15(5):2191-201. doi: 10.1093/nar/15.5.2191.

DOI:10.1093/nar/15.5.2191
PMID:3562225
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC340626/
Abstract

The hexamer d(CGm4CGCG) exists predominantly as a right handed B form helix at 20 degrees C in 150 mM NaCl, as shown by 2D NOE spectra. Under these conditions a minor species is also observed which corresponds to the single strand in slow exchange on a proton NMR time scale with the double strand. This exchange is unusually slow and separate resonances for the two species are seen up to 65 degrees C. At 50 degrees C the lifetime of the single strand species is 0.85 s. Under high salt conditions the hexamer is partly converted into the Z form, but the complete transition is only observed at 5M NaCl at -6 degrees C.

摘要

二维NOE谱表明，六聚体d(CGm4CGCG)在150 mM NaCl中、20℃时主要以右手B型螺旋形式存在。在这些条件下，还观察到一种次要物种，它在质子NMR时间尺度上与双链进行缓慢交换，对应于单链。这种交换异常缓慢，在高达65℃时仍能看到两种物种的独立共振峰。在50℃时，单链物种的寿命为0.85秒。在高盐条件下，六聚体部分转化为Z型，但只有在-6℃、5M NaCl时才观察到完全转变。