Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China.
Curr Hypertens Rep. 2014 Feb;16(2):415. doi: 10.1007/s11906-013-0415-7.
Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in patients with heart failure and coronary artery disease. Low levels of urinary corin also have been found in patients with chronic kidney disease. Most recent studies show that corin also acts in the uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Here, we review the role of corin in natriuretic peptide processing and cardiovascular diseases such as hypertension, heart disease, pre-eclampsia, and chronic kidney disease.
科林是一种丝氨酸蛋白酶，最初从心脏中分离得到。功能研究表明，科林是长期以来寻找的负责激活心脏利钠肽的酶。在小鼠中，缺乏科林会阻止利钠肽的加工，导致盐敏感性高血压。在人类中，已经在高血压和心力衰竭患者中发现了科林变体和降低科林活性的突变。心力衰竭和冠状动脉疾病患者的血浆科林抗原和活性水平降低。慢性肾病患者的尿科林水平也较低。最近的研究表明，科林还在子宫中发挥作用，促进螺旋动脉重塑，预防妊娠高血压。在这里，我们回顾了科林在利钠肽加工和心血管疾病（如高血压、心脏病、子痫前期和慢性肾病）中的作用。
