Corin在血压调节中的作用。
Role of corin in the regulation of blood pressure.
作者信息
Li Hui, Zhang Yue, Wu Qingyu
机构信息
aCyrus Tang Hematology Center, MOE Engineering Center of Hematological Disease, and Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China bMolecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Curr Opin Nephrol Hypertens. 2017 Mar;26(2):67-73. doi: 10.1097/MNH.0000000000000297.
PURPOSE OF REVIEW
Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases.
RECENT FINDINGS
Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia. Reduced corin expression has been detected in animal models of cardiomyopathies and in human failing hearts. Low levels of circulating soluble corin have been reported in patients with heart disease and stroke. Corin, ANP and natriuretic peptide receptor-A mRNAs, and proteins have been colocalized in human renal segments, suggesting a corin-ANP autocrine function in the kidney.
SUMMARY
Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.
综述目的
Corin是一种跨膜蛋白酶，可激活心房利钠肽（ANP），ANP是调节水盐平衡和血压的重要激素。本综述重点关注Corin功能的调节以及Corin缺陷在高血压、心脏和肾脏疾病中的潜在作用。
最新发现
前蛋白转化酶枯草杆菌蛋白酶/kexin-6已被确定为将无活性的Corin转化为活性蛋白酶的主要酶。在高血压、心脏肥大和先兆子痫患者中发现了损害Corin细胞内运输、细胞表面表达和酶原激活的基因变异。在心肌病动物模型和人类衰竭心脏中检测到Corin表达降低。心脏病和中风患者中循环可溶性Corin水平较低。Corin、ANP和利钠肽受体-A的mRNA及蛋白已在人类肾段中共定位，提示肾脏中存在Corin-ANP自分泌功能。
总结
Corin是利钠肽系统中的关键酶。最新研究结果表明，Corin介导的ANP产生可能以组织特异性方式调节心血管和肾脏功能。Corin缺陷可能导致高血压、心力衰竭、先兆子痫和肾脏疾病等重大疾病。
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