Zhang Rui, Song Chun
Department of Intestine Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, 110042, People's Republic of China.
Tumour Biol. 2014 May;35(5):4419-23. doi: 10.1007/s13277-013-1581-6. Epub 2014 Jan 10.
CUB and sushi multiple domain protein 1 (CSMD1) is a candidate tumor suppressor gene. The three members of CSMD family have very similar structures, each consisting of 14 CUB domains separated from one another by a sushi domain, an additional uninterrupted array of sushi domains, a single transmembrane domain, and a short cytoplasmic tail. In this work, we aimed to study the protein and mRNA levels of the CSMD1, CSMD2, and CSMD3 and evaluate their prognostic importance in colorectal cancer. Reduced expressions of these three proteins were detected in colorectal cancer tissues by comparing matched normal tissues. Low CSMD2 expression was significantly associated with differentiation, lymphatic invasion, and tumor size. CSMD3 was associated with differentiation and lymphatic invasion. CSMD1 and CSMD2 expressions were associated with overall survival. This study offers convincing evidence for the first time that the three genes of CSMD family were downregulated in the patients with colorectal cancer and may be used as predictors of colorectal cancer.
CUB和寿司多结构域蛋白1（CSMD1）是一种候选肿瘤抑制基因。CSMD家族的三个成员具有非常相似的结构，每个成员都由14个CUB结构域组成，这些结构域被一个寿司结构域、一个额外的连续寿司结构域阵列、一个单一的跨膜结构域和一个短的细胞质尾巴彼此隔开。在这项研究中，我们旨在研究CSMD1、CSMD2和CSMD3的蛋白质和mRNA水平，并评估它们在结直肠癌中的预后重要性。通过比较匹配的正常组织，在结直肠癌组织中检测到这三种蛋白质的表达降低。低CSMD2表达与分化、淋巴浸润和肿瘤大小显著相关。CSMD3与分化和淋巴浸润相关。CSMD1和CSMD2表达与总生存期相关。本研究首次提供了令人信服的证据，证明CSMD家族的这三个基因在结直肠癌患者中表达下调，并且可能用作结直肠癌的预测指标。
