Pietro Dulbecco, Vincenzo Savarino, Department of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.
World J Gastroenterol. 2013 Dec 28;19(48):9256-70. doi: 10.3748/wjg.v19.i48.9256.
Curcumin is a low-molecular-weight hydrophobic polyphenol that is extracted from turmeric, which possesses a wide range of biological properties including anti-inflammatory, anti-oxidant, anti-proliferative and anti-microbial activities. Despite its diverse targets and substantial safety, clinical applications of this molecule for digestive disorders have been largely limited to case series or small clinical trials. The poor bioavailability of curcumin is likely the major hurdle for its more widespread use in humans. However, complexation of curcumin into phytosomes has recently helped to bypass this problem, as it has been demonstrated that this new lecithin formulation enables increased absorption to a level 29-fold higher than that of traditional curcuminoid products. This allows us to achieve much greater tissue substance delivery using significantly lower doses of curcumin than have been used in past clinical studies. As curcumin has already been shown to provide good therapeutic results in some small studies of both inflammatory and neoplastic bowel disorders, it is reasonable to anticipate an even greater efficacy with the advent of this new technology, which remarkably improves its bioavailability. These features are very promising and may represent a novel and effective therapeutic approach to both functional and organic digestive diseases.
姜黄素是一种低分子量疏水性多酚，从姜黄中提取而来，具有广泛的生物学特性，包括抗炎、抗氧化、抗增殖和抗菌活性。尽管这种分子的靶点多样且安全性高，但它在消化疾病方面的临床应用主要局限于病例系列或小型临床试验。姜黄素的生物利用度差可能是其在人类中更广泛应用的主要障碍。然而，最近将姜黄素复合到植物固醇体中有助于克服这个问题，因为已经证明这种新的卵磷脂配方可以使吸收增加 29 倍，高于传统姜黄素产品的吸收水平。这使得我们能够以比过去临床研究中使用的更低剂量实现更高的组织物质传递。由于姜黄素在一些炎症和肿瘤性肠病的小型研究中已经显示出良好的治疗效果，因此随着这项新技术的出现，我们有理由预期其疗效更大，因为这项新技术显著提高了其生物利用度。这些特点非常有前途，可能代表了一种治疗功能性和器质性消化疾病的新的有效治疗方法。
