TWEAK是自身免疫性/慢性炎症性疾病的生物标志物吗？
Is TWEAK a Biomarker for Autoimmune/Chronic Inflammatory Diseases?
作者信息
Bertin Daniel, Stephan Delphine, Khrestchatisky Michel, Desplat-Jégo Sophie
机构信息
Aix-Marseille Université, NICN, CNRS, UMR7259 , Marseille , France ; Service d'Immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille , Marseille , France.
Aix-Marseille Université, NICN, CNRS, UMR7259 , Marseille , France.
出版信息
Front Immunol. 2013 Dec 27;4:489. doi: 10.3389/fimmu.2013.00489.
Abstract
The TWEAK/Fn14 pathway is now well-known for its involvement in the modulation of inflammation in various human autoimmune/chronic inflammatory diseases (AICID) including lupus, rheumatoid arthritis, and multiple sclerosis. A panel of data is now available concerning TWEAK expression in tissues or biological fluids of patients suffering from AICID, suggesting that it could be a promising biological marker in these diseases. Evidences from several teams support the hypothesis that blocking TWEAK/Fn14 pathway is an attractive new therapeutic lead in such diseases and clinical trials with anti-TWEAK-blocking antibodies are in progress. In this mini-review we discuss the potential use of TWEAK quantification in AICD management in routine practice and highlight the challenge of standardizing data collection to better estimate the clinical utility of such a biological parameter.
摘要
TWEAK/Fn14信号通路因参与调控多种人类自身免疫性/慢性炎症性疾病（AICID）（包括狼疮、类风湿性关节炎和多发性硬化症）中的炎症反应而广为人知。目前已有一系列关于AICID患者组织或生物体液中TWEAK表达的数据，这表明它可能是这些疾病中有前景的生物标志物。多个研究团队的证据支持这样一种假说，即阻断TWEAK/Fn14信号通路是这类疾病一种有吸引力的新治疗方向，并且针对抗TWEAK阻断抗体的临床试验正在进行。在本综述中，我们讨论了在常规实践中TWEAK定量在AICD管理中的潜在用途，并强调了标准化数据收集以更好地评估这种生物参数临床效用的挑战。
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