Mu Chunlong, Zhu Weiyun
Laboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, Nanjing 210095, China.
Wei Sheng Wu Xue Bao. 2013 Oct 4;53(10):1018-24.
The intestinal environment is dependent on the host-microbiota interaction. Antigens of gut microbiota could affect the intestinal immunological homeostasis. Gut microbiota also participate in the metabolism of carbohydrate, lipid and protein. In return, the metabolites from these metabolic processes could regulate the bacterial metabolism, community composition and intestinal nutrient assimilation. MicroRNA serves as an important intracellular factor that regulates host gene expression. Gut microbiota could affect the host mRNA transcription and the post-transcription modification of certain genes by microRNA. Recent researches have revealed that gut microbiota could change the expression of microRNAs involved in gut inflammation and mucosal barrier via host-microbiota interaction. In this paper, we summarized recent advances in host-microbiota interaction and highlighted the research about microRNA regulation on gut homeostasis and host-microbiota interaction.
肠道环境依赖于宿主-微生物群的相互作用。肠道微生物群的抗原可影响肠道免疫稳态。肠道微生物群还参与碳水化合物、脂质和蛋白质的代谢。作为回报，这些代谢过程产生的代谢产物可调节细菌代谢、群落组成和肠道营养吸收。微小RNA作为调节宿主基因表达的重要细胞内因子。肠道微生物群可通过微小RNA影响宿主mRNA转录和某些基因的转录后修饰。最近的研究表明，肠道微生物群可通过宿主-微生物群相互作用改变参与肠道炎症和黏膜屏障的微小RNA的表达。在本文中，我们总结了宿主-微生物群相互作用的最新进展，并重点介绍了关于微小RNA对肠道稳态和宿主-微生物群相互作用调节的研究。
