El Haj Mohamad, Moroni Christine, Luyat Marion, Omigie Diana, Allain Philippe
a Laboratoire Epsylon, Université Paul-Valery , Montpellier III, Montpellier , France.
J Clin Exp Neuropsychol. 2014;36(2):127-36. doi: 10.1080/13803395.2013.869309. Epub 2014 Jan 13.
We compared destination memory to source memory in patients with Alzheimer's disease (AD), as the latter type of memory is believed to be severely deteriorated in AD. Control participants and AD patients were tested on two conditions, both of which had a study phase and a recognition phase. In the study phase of the first condition, participants had to tell a set of facts to the faces of a set of celebrities (destination memory). In the study phase of the second condition, they had to receive a different set of facts from a different set of celebrity faces (source memory). During the recognition phase, participants had to indicate, for destination memory, whether they had previously told a given fact to a given face (yes) or not (no) and, for source memory, whether they had previously received a given fact from a given face (yes) or not (no). In both conditions, they were asked to choose between "remember" or "know" options when answering "yes." AD patients showed reliable difficulties in destination recall, accompanied by a significant decrease in the number of "remember" responses they gave. AD-related destination memory decline may be attributed to the perturbation of episodic memory and its autonoetic reliving. The potential neural bases of this decline are discussed in terms of hippocampal failures.
我们将阿尔茨海默病（AD）患者的情景记忆与源记忆进行了比较，因为人们认为后一种记忆类型在AD中会严重衰退。对对照组参与者和AD患者在两种条件下进行了测试，这两种条件都有一个学习阶段和一个识别阶段。在第一种条件的学习阶段，参与者必须对着一组名人的面孔讲述一组事实（情景记忆）。在第二种条件的学习阶段，他们必须从另一组名人面孔中接收另一组事实（源记忆）。在识别阶段，对于情景记忆，参与者必须指出他们之前是否将一个给定事实告诉过一张给定面孔（是）或没有（否），对于源记忆，他们必须指出他们之前是否从一张给定面孔中接收过一个给定事实（是）或没有（否）。在两种条件下，当回答“是”时，他们被要求在“记得”或“知道”选项之间进行选择。AD患者在情景回忆方面表现出明显的困难，同时他们给出的“记得”反应数量显著减少。与AD相关的情景记忆衰退可能归因于情景记忆及其自我体验式重现的扰动。从海马体功能障碍的角度讨论了这种衰退的潜在神经基础。
