J Org Chem. 2014 Feb 7;79(3):993-1000. doi: 10.1021/jo4024864.
Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.
介绍了富电子 2-取代-6-(苯磺酰基)吡啶的合成方法。通过相应的磺酰基吡啶的立体选择性 S(N)Ar 取代反应，设计并合成了一系列稳定、可调谐、P-手性吡啶二氢苯并氧杂磷杂环戊烯配体。这些配体成功地应用于非官能化烯烃的 Ir 催化不对称氢化反应，具有良好的对映选择性。
