间充质干细胞：在血管生成中的作用和关系。
Mesenchymal stem cells: roles and relationships in vascularization.
机构信息
Fischell Department of Bioengineering, University of Maryland , College Park, Maryland.
出版信息
Tissue Eng Part B Rev. 2014 Jun;20(3):218-28. doi: 10.1089/ten.TEB.2013.0541. Epub 2014 Feb 19.
Abstract
One of the primary challenges in translating tissue engineering to clinical applicability is adequate, functional vascularization of tissue constructs. Vascularization is necessary for the long-term viability of implanted tissue expanded and differentiated in vitro. Such tissues may be derived from various cell sources, including mesenchymal stem cells (MSCs). MSCs, able to differentiate down several lineages, have been extensively researched for their therapeutic capabilities. In addition, MSCs have a variety of roles in the vascularization of tissue, both through direct contact and indirect signaling. The studied relationships between MSCs and vascularization have been utilized to further the necessary advancement of vascularization in tissue engineering concepts. This review aims to provide a summary of relevant relationships between MSCs, vascularization, and other relevant cell types, along with an overview discussing applications and challenges related to the roles and relationships of MSCs and vascular tissues.
摘要
将组织工程转化为临床应用的主要挑战之一是组织构建物的充分、功能性血管化。血管化对于体外扩增和分化的植入组织的长期存活是必要的。这些组织可以来自各种细胞来源，包括间充质干细胞（MSCs）。MSCs 能够向多个谱系分化，因其治疗能力而得到广泛研究。此外，MSCs 在组织的血管生成中具有多种作用，包括直接接触和间接信号传递。已经研究了 MSCs 与血管生成之间的关系，以进一步推动组织工程概念中血管生成的必要进展。本综述旨在提供 MSCs、血管生成和其他相关细胞类型之间的相关关系的概述，并讨论与 MSCs 和血管组织的作用和关系相关的应用和挑战。
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